50多年前引入抗Rh（D）免疫球蛋白，由于这种预防方法的摄取较低，全球恒河猴疾病仅减少了50％。国际妇产科联合会，国际助产士联合会，和全球根除恒河猴疾病倡议已经审查了有关抗Rh（D）免疫球蛋白效用的现有证据。考虑到反Rh(D)的有效性，新指南建议调整不同适应症的剂量，并按适应症优先给药。
The introduction of anti-Rh(D) immunoglobulin more than 50 years ago has resulted in only a 50% decrease in Rhesus disease globally owing to a low uptake of this prophylactic approach. The International Federation of Gynecology and Obstetrics, International Confederation of Midwives, and Worldwide Initiative for Rhesus Disease Eradication have reviewed current evidence regarding the utility of anti-Rh(D) immunoglobulin. Taking into account the effectiveness anti-Rh(D), the new
guidelines propose adjusting the dose for different indications and prioritizing its administration by indication.
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