口腔鳞状细胞癌(OSCC)是一种预后不良的口腔恶性肿瘤。涉及葡萄糖转运蛋白(GLUT)的糖酵解途径中的失调与不良预后有关。此外,GLUT在癌细胞中的表达受几种miRNA调控。然而,缺乏有关OSCC中参与GLUT调控的miRNA的数据。目标是评价miRNA在OSCC中GLUT调控中的感化。数据源包括PubMed(MEDLINE)、Scopus,和WebofScience。系统评价了OSCC中与GLUT调控相关的miRNA的研究。从研究中提取与GLUT和相关miRNA表达有关的数据。对GLUT和miRNA进行定性评估。纽卡斯尔-渥太华量表用于质量评估。在分析了4675篇论文后,纳入了10篇研究文章。这些研究评估了健康和OSCC样品之间的GLUT和miRNA表达。在OSCC中存在GLUT的可变表达模式。此外,它依赖于miRNA。GLUT1和GLUT-3在OSCC中被更频繁地检测到,而没有研究揭示GLUT2、GLUT4、GLUT7、GLUT8、GLUT13、SGLT1和SGLT2的表达与miRNA调控。然而,关于与GLUT1或GLUT3表达相关的特异性miRNA的证据不足.有证据表明miRNA在OSCC中对GLUT尤其是GLUT1和GLUT3的调控中的作用;然而,与miRNA的特定关系研究不足.在未来,有必要对miRNA和GLUT代谢途径与OSCC相关的相关性进行更清晰的了解。此外,miRNA和GLUT与疾病进展的关联,抗病性,并评估预后以获得更好的治疗结果。
Oral squamous cell carcinoma (OSCC) is a malignancy of the oral cavity with poor prognosis. Dysregulation in glycolytic pathways involving glucose transporters (GLUT) has been implicated in poor prognosis. Furthermore, GLUT
expression in cancer cells is regulated by several miRNAs. However, there is a lack of data about miRNA involved in the regulation of GLUT in OSCC. The objective is to evaluate the role of miRNA in the regulation of GLUT in OSCC. Data sources include PubMed (MEDLINE), Scopus, and Web of Science. Studies evaluating the miRNA involved or associated with the regulation of GLUT in OSCC were included in the systematic
review. Data pertaining to GLUT and associated miRNA
expression were extracted from studies. Qualitative assessment was carried out for GLUT and miRNA. The Newcastle-Ottawa Scale was used for quality assessment. Ten study articles were included after analyzing 4675 papers. These studies evaluated the GLUT and miRNA
expression between healthy and OSCC samples. There are variable
expression patterns of GLUT in OSCC. Furthermore, it was dependent on miRNA. The GLUT1 and GLUT-3 were detected more frequently in OSCC, while no study reveals the expression of GLUT2, GLUT4, GLUT7, GLUT8, GLUT13, SGLT1, and SGLT2 with miRNA regulation. However, there was insufficient evidence on specific miRNA linked to GLUT1 or GLUT3 expression. There is evidence of the role of miRNA in the regulation of GLUT especially GLUT1 and GLUT3 in OSCC; however, a specific relation to miRNA was understudied. In the future, studies exploring a clearer understanding of the association between miRNA and the GLUT metabolic pathway in relation to OSCC are warranted. Furthermore, association of miRNA and GLUT with progression of disease, disease resistance, and prognosis is assessed for better treatment outcomes.