Behçet综合征(BS)是一种罕见的变异型血管炎,可累及眼睛和胃肠道系统。然而,眼部受累很少与肠道病变重叠。本研究旨在比较我国眼部BS和肠道BS患者的临床特征和实验室指标,并分析两种关键表型的差异,以验证BS患者的异质性状况。
使用回顾性分析来收集人口统计数据,临床特征,内镜检查结果,135例眼部BS和174例肠道BS患者的实验室参数。采用Mann-WhitneyU检验和Pearson卡方或连续性校正分析两组间的差异。
在这项研究中纳入的916例BS患者中,眼BS和肠BS分别占14.74%(135例)和19.00%(174例),分别。仅7例(0.76%)眼部和肠道受累重叠。男性(74.8%vs.51.1%,P=0.00),结节性红斑(45.9%vs.32.2%,P=0.01),和血管受累(6.7%vs.1.7%,与肠道BS组相比,眼部BS组的P=0.03)频率更高。相反,血液学受累(7.5%vs.0.0%,P=0.00)和发烧(17.8%vs.4.4%,与眼部BS组相比,肠道BS组的P=0.00)频率更高。此外,炎症标志物包括ESR[26.5(16.0-41.5)与9.0(5.0-15.0)mm/H,P=0.00],CRP[14.8(4.8-33.0)vs.4.1(1.6-8.3)mg/L,P=0.00],血清淀粉样蛋白A[27.4(10.8-92.3)vs.11.3(6.0-24.0)mg/L,P=0.00],和白细胞介素6[8.4(1.7-18.7)与1.7(1.5-3.2)pg/mL,肠BS组P=0.00]高于眼BS组,分别。
眼部BS在男性患者中更为普遍,更可能表现为结节性红斑和血管受累。而肠道BS往往有发热和血液系统疾病,炎症标志物较高。眼部BS和肠道BS是两种不同的临床表型,很少重叠。
Behçet\'s syndrome (BS) is a rare variant vasculitis which can involve the eyes and gastrointestinal systems. However, ocular involvement rarely overlaps with intestinal lesions. This
study aimed to compare the clinical characteristics and laboratory parameters of ocular BS and intestinal BS patients in China and analyze the differences between two key phenotypes to verify the heterogeneous conditions in BS patients.
A retrospective analysis was used to collect the demographic data, clinical characteristics, endoscopic findings, and laboratory parameters from 135 ocular BS and 174 intestinal BS patients. The Mann-Whitney U test and Pearson chi-square or continuity correction was used to analyze the differences between two groups.
Among 916 BS patients enrolled in this
study, ocular BS and intestinal BS accounted for 14.74% (135 cases) and 19.00% (174 cases), respectively. Ocular and intestinal involvements overlapped in only 7 cases (0.76%). Male gender (74.8% vs. 51.1%, P=0.00), erythema nodosum (45.9% vs. 32.2%, P=0.01), and vascular involvement (6.7% vs. 1.7%, P=0.03) were more frequent in the ocular BS group compared with the intestinal BS group. On the contrary, hematologic involvement (7.5% vs. 0.0%, P=0.00) and fever (17.8% vs. 4.4%, P=0.00) were more frequent in the intestinal BS group compared with the ocular BS group. Additionally, the inflammation markers including ESR [26.5 (16.0-41.5) vs. 9.0 (5.0-15.0) mm/H, P=0.00], CRP [14.8 (4.8-33.0) vs. 4.1 (1.6-8.3) mg/L, P=0.00], serum amyloid A [27.4 (10.8-92.3) vs. 11.3 (6.0-24.0) mg/L, P=0.00], and interleukin 6 [8.4 (1.7-18.7) vs. 1.7 (1.5-3.2) pg/mL, P=0.00] were higher in the intestinal BS group than those in the ocular BS group, respectively.
Ocular BS was more prevalent in male patients and more likely to manifest with erythema nodosum and vascular involvement, while intestinal BS tends to have fever and hematologic disorders with higher inflammation markers. Ocular BS and intestinal BS are two distinct clinical phenotypes and very rarely overlapped.