Abstract：
BACKGROUND: Erythema Nodosum (EN) is the most common skin manifestation in sarcoidosis and has often been associated with a good prognosis.
OBJECTIVE: To compare the clinical characteristics and treatment-related features in patients with sarcoidosis according to whether or not EN was seen as a presenting symptom at the time of diagnosis.
METHODS: A 20-year single-center retrospective study was performed. The following two groups were identified: one group with EN as one of the presenting symptoms at the time of diagnosis of sarcoidosis (EN group) and a second group without EN as a presenting symptom at diagnosis (non-EN group). The clinical characteristics and treatment modalities were collected from the medical records.
RESULTS: A total of 122 patients (31 in the EN group, 91 in the non-EN group) were included. Radiological stages of pulmonary disease were significantly lower in the EN group. Articular involvement was more common in the EN group (p = 0.001), whereas other systemic organ involvements (p = 0.025), especially neurological involvement (p = 0.036), were significantly more common in the non-EN group. In the EN group, a higher percentage of patients were managed without systemic therapy (71.0% vs. 54.9%) and spontaneous remission was more frequent (25.0% vs. 14.1%), however, this wasn\'t statistically significant.
CONCLUSIONS: Retrospective design.
CONCLUSIONS: The lower radiological stage of pulmonary sarcoidosis and lower frequency of systemic organ involvement in patients with EN augment the prognostic value of EN highlighted in the literature. However, this study couldn\'t confirm that the patients with EN would need less systemic therapy in the course of their disease.
OBJECTIVE: To compare the clinical characteristics and treatment-related features in patients with sarcoidosis according to whether or not EN was seen as a presenting symptom at the time of diagnosis.
METHODS: A 20-year single-center retrospective study was performed. The following two groups were identified: one group with EN as one of the presenting symptoms at the time of diagnosis of sarcoidosis (EN group) and a second group without EN as a presenting symptom at diagnosis (non-EN group). The clinical characteristics and treatment modalities were collected from the medical records.
RESULTS: A total of 122 patients (31 in the EN group, 91 in the non-EN group) were included. Radiological stages of pulmonary disease were significantly lower in the EN group. Articular involvement was more common in the EN group (p = 0.001), whereas other systemic organ involvements (p = 0.025), especially neurological involvement (p = 0.036), were significantly more common in the non-EN group. In the EN group, a higher percentage of patients were managed without systemic therapy (71.0% vs. 54.9%) and spontaneous remission was more frequent (25.0% vs. 14.1%), however, this wasn\'t statistically significant.
CONCLUSIONS: Retrospective design.
CONCLUSIONS: The lower radiological stage of pulmonary sarcoidosis and lower frequency of systemic organ involvement in patients with EN augment the prognostic value of EN highlighted in the literature. However, this study couldn\'t confirm that the patients with EN would need less systemic therapy in the course of their disease.
摘要：
背景：结节性红斑（EN）是结节病中最常见的皮肤表现，通常与良好的预后有关。
目的：根据诊断时是否将EN视为表现症状，比较结节病患者的临床特征和治疗相关特征。
方法：进行为期20年的单中心回顾性研究。确定了以下两组：一组在诊断结节病时将EN作为表现症状之一（EN组），第二组在诊断时未将EN作为表现症状（非EN组）。从病历中收集临床特征和治疗方式。
结果：共有122名患者（EN组31名，非EN组91）包括在内。EN组肺部疾病的放射学分期显着降低。关节受累在EN组更为常见（p=0.001），而其他全身器官受累（p=0.025），尤其是神经系统受累（p=0.036），在非EN组中更为常见。在EN组中，在没有全身治疗的情况下接受治疗的患者比例更高(71.0%vs.54.9%）和自发缓解更频繁（25.0%vs.14.1%），然而,这没有统计学意义。
结论：回顾性设计。
结论：EN患者的肺结节病的放射学分期较低，全身器官受累的频率较低，增强了文献中强调的EN的预后价值。然而,这项研究无法证实EN患者在病程中需要更少的全身治疗.
目的：根据诊断时是否将EN视为表现症状，比较结节病患者的临床特征和治疗相关特征。
方法：进行为期20年的单中心回顾性研究。确定了以下两组：一组在诊断结节病时将EN作为表现症状之一（EN组），第二组在诊断时未将EN作为表现症状（非EN组）。从病历中收集临床特征和治疗方式。
结果：共有122名患者（EN组31名，非EN组91）包括在内。EN组肺部疾病的放射学分期显着降低。关节受累在EN组更为常见（p=0.001），而其他全身器官受累（p=0.025），尤其是神经系统受累（p=0.036），在非EN组中更为常见。在EN组中，在没有全身治疗的情况下接受治疗的患者比例更高(71.0%vs.54.9%）和自发缓解更频繁（25.0%vs.14.1%），然而,这没有统计学意义。
结论：回顾性设计。
结论：EN患者的肺结节病的放射学分期较低，全身器官受累的频率较低，增强了文献中强调的EN的预后价值。然而,这项研究无法证实EN患者在病程中需要更少的全身治疗.
