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Abstract：
Background: Sarcoidosis is a multisystem granulomatous disease with a wide variety of presentations and clinical courses. Cutaneous manifestations and comorbidities associated with sarcoid prognosis remain understudied. Methods: An EPIC query was run for patients age 18+ at the Johns Hopkins Hospital with a diagnosis of sarcoidosis of the skin according to the ICD-10-CM code D86.3. Data were obtained from a population-based sample of 240 patients from 2015 to 2020. Results: A total of 240 patients were included in the cohort study. The mean (SD) age was 43.76 (11.72) years, and 30% of participants were male; 76.25% of patients identified as black, 19.58% as white, and 4.17% as other. The average age of onset in remissive patients was significantly higher than progressive (47 ± 12 vs. 40 ± 10, p = 0.0005); 49% of black patients experienced progressive sarcoid compared to 32.6% of white patients (p = 0.028). Progressive disease was associated with the presence of lupus pernio (aOR = 3.29, 95% CI, 1.60-6.77) and at least one autoimmune comorbidity (aOR 6.831, 95% CI 1.819-11.843). Conclusions: When controlling for patient demographics, lupus pernio and the presence of at least one autoimmune condition were associated with progressive cutaneous sarcoidosis.
摘要：
背景：结节病是一种多系统肉芽肿性疾病，表现和临床过程多种多样。与结节病预后相关的皮肤表现和合并症仍未得到充分研究。方法：根据ICD-10-CM代码D86.3，在约翰霍普金斯医院对18岁以上的患者进行EPIC查询，诊断为皮肤结节病数据来自2015年至2020年的240名患者的基于人群的样本。结果：共有240例患者被纳入队列研究。平均(SD)年龄为43.76(11.72)岁,30％的参与者是男性;76.25％的患者被确定为黑人，19.58%为白色，和其他4.17%。缓解期患者的平均发病年龄明显高于进展期（47±12vs.40±10，p=0.0005）；49％的黑人患者经历了进行性结节病，而白人患者为32.6％（p=0.028）。进展性疾病与狼疮的存在相关（aOR=3.29，95％CI，1.60-6.77）和至少一种自身免疫性共病（aOR6.831，95％CI1.819-11.843）。结论：在控制患者人口统计学时，狼疮和至少一种自身免疫性疾病的存在与进行性皮肤结节病有关。
