■先前的研究表明,肠道微生物群与皮肤病之间存在联系,包括丹毒,炎症性皮肤病.尽管如此,丹毒与肠道微生物群之间关系的确切性质尚不清楚,尚有争议.
■我们使用来自全基因组关联研究(GWAS)的公开汇总数据进行了孟德尔随机化(MR)分析,以探索肠道微生物群与丹毒之间的潜在因果关系。使用一套全面的筛选方法鉴定工具变量(IVs)。然后,我们主要使用逆方差加权(IVW)方法进行MR分析,辅以诸如MREgger之类的替代方法,加权中位数,简单模式,和加权模式。一系列的敏感性分析,包括Cochran的Q测试,MR-Egger截距测试,孟德尔随机化多向性和异常值(MR-PRESSO)试验,和一次离开测试,执行是为了确保我们发现的稳健性和有效性。
■我们确定了丹毒和各种肠道微生物群之间的潜在关联,包括Alcaligenaceae(OR1.23;95%CI1.06-1.43;p=0.006),利肯纳尔科(OR0.77;95%CI0.67-0.90;p=0.001),和其他人。值得注意的是,与放线菌的关联,落叶松科NC2004组,Ruminiclostridium9,RuminococaceaeUCG014,Odoribacter,还观察到放线菌。敏感性分析证实了这些关联的稳健性。
■我们的MR分析表明,各种肠道微生物群与丹毒发生率之间存在潜在的有益和有害因果关系。这项研究为丹毒的发病机理提供了新的理论和经验见解,并强调了创新预防和治疗方法的潜力。
UNASSIGNED: Previous studies have suggested a link between gut microbiota and skin diseases, including
erysipelas, an inflammatory skin condition. Despite this, the precise nature of the relationship between
erysipelas and gut microbiota remains unclear and subject to debate.
UNASSIGNED: We conducted a Mendelian Randomization (MR) analysis using publicly available summary data from genome-wide association studies (GWAS) to explore the potential causal relationship between gut microbiota and
erysipelas. Instrumental variables (IVs) were identified using a comprehensive set of screening methods. We then performed MR analyses primarily using the Inverse Variance Weighted (IVW) method, complemented by alternative approaches such as MR Egger, weighted median, simple mode, and weighted mode. A series of sensitivity analyses, including Cochran\'s Q test, MR-Egger intercept test, Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test, and a leave-one-out test, were executed to ensure the robustness and validity of our findings.
UNASSIGNED: We identified potential associations between
erysipelas and various gut microbiota, including Alcaligenaceae (OR 1.23; 95% CI 1.06-1.43; p=0.006), Rikenellaceae (OR 0.77; 95% CI 0.67-0.90; p=0.001), and others. Notably, associations with Actinomyces, Lachnospiraceae NC2004 group, Ruminiclostridium 9, Ruminococcaceae UCG014, Odoribacter, and Actinobacteria were also observed. Sensitivity analyses confirmed the robustness of these associations.
UNASSIGNED: Our MR analysis suggests both potentially beneficial and harmful causal relationships between various gut microbiota and the incidence of erysipelas. This study provides new theoretical and empirical insights into the pathogenesis of
erysipelas and underscores the potential for innovative preventive and therapeutic approaches.