5-羟色胺(5-HT)及其神经营养支持系统,特别是脑源性神经营养因子(BDNF),被认为可以调节能量稳态和肥胖的易感性。此外,5-羟色胺再摄取转运蛋白(5-HTT)基因中的多态性(5-HTTLPR)损害其转录,从而改变血清素能张力并可能导致这种易感性。本研究旨在探讨BDNF的作用,双等位基因5-HTTLPR,使用正电子发射断层扫描(PET)和5-HTT选择性[(11)C]DASB,高度肥胖和非肥胖受试者的中央体内5-HTT可用性。
38个科目,24肥胖,否则精神和身体健康,14名非肥胖健康对照纳入本研究.从PET数据生成结合电位的参数图像。中央5-HTT可用性,5-HTTLPR基因型,和血清BDNF浓度分析,首先是感兴趣的一卷,然后以体素的方式。
总的来说,我们的结果表明BDNF之间没有线性相关,体内中央5-HTT可用性,体重指数(BMI)。5-HTTLPR基因分型显示,在长等位基因纯合子中,BDNF和海马5-HTT可用性呈负相关(r=-0.57,p=0.007)。然而,与我们的非肥胖对照相比,肥胖受试者的BDNF水平对伏隔核(NAcc)中5-HTT的可利用性表现出相反的作用.
我们的数据没有证实血清BDNF之间的整体相关性,体内中央5-HTT可用性,5-HTTLPR,BMI。然而,有证据表明血清素能与BDNF有关,特别是在NAcc中,与肥胖的病理生理学有关,尽管这需要对广泛的与奖励相关的饮食行为进行进一步的探索。
Serotonin (5-HT) and its neurotrophic support system, specifically brain-derived neurotrophic factor (BDNF), are thought to modulate energy homeostasis and susceptibility to obesity. Moreover, a polymorphism (5-HTTLPR) in the serotonin reuptake transporter (5-HTT) gene impairs its transcription, thereby altering serotonergic tone and potentially contributing to such susceptibility. This
study aims to investigate the effect of BDNF, biallelic 5-HTTLPR, and central in-vivo 5-HTT availability in highly obese versus non-obese subjects using positron emission tomography (PET) and 5-HTT selective [(11)C]DASB.
Thirty-eight subjects, 24 obese, otherwise mentally and physically healthy, and 14 non-obese healthy controls were included in this
study. Parametric images of binding potential were generated from PET data. Central 5-HTT availability, 5-HTTLPR genotype, and serum BDNF concentrations were analyzed, first in a volume of interest, then in a voxel-wise manner.
Overall, our results showed an absence of a linear correlation between BDNF, in-vivo central 5-HTT availability, and body mass index (BMI). 5-HTTLPR genotyping revealed BDNF and hippocampal 5-HTT availability to be negatively correlated (r = -0.57, p = 0.007) in long allelic homozygotes. However, obese subjects exhibited opposing effects of BDNF levels on 5-HTT availability in the nucleus accumbens (NAcc) relative to our non-obese controls.
Our data did not confirm an overall correlation between serum BDNF, in-vivo central 5-HTT availability, 5-HTTLPR, and BMI. However, there is evidence that serotonergic tone linked to BDNF, specifically in the NAcc, is involved in the pathophysiology of obesity, although this needs further exploration over a wide range of reward-related eating behaviors.