■阿拉伯联合酋长国(UAE),以其特有的当地人口,地理,和历史,提出了肥胖个体心血管疾病(CVDs)的几个危险因素。肥胖及其相关并发症,包括糖尿病,致动脉粥样硬化的血脂异常,和CVD导致重大健康风险。在本研究中,“青年”定义为18至22岁的年轻人。我们评估了血脂异常,炎症,UAE超重/肥胖和体重正常的年轻人的氧化应激生物标志物水平及其与内皮功能障碍(ED)的关系。
■有160名超重/肥胖(BMI≥25kg/m2)患者和健康年龄和性别匹配的正常体重(BMI≤24.9kg/m2)的年轻人参加了这项研究。收集人体测量数据和血液样本以评估血脂异常的生物标志物,炎症,氧化应激,所有年轻人的ED。
■总体平均年龄和男女比例分别为20±1.5岁和1.0:1.2。HDL-C差异有统计学意义(p<0.001),甘油三酯(TG)(p<0.001),ApoA(p=0.002),超重/肥胖和体重正常的年轻人之间的ApoB/ApoA比率(p=0.009)。其中,炎症标志物:hs-CRP,IL-6,TNF-α也显示显著p<0.001和氧化应激标记:DNA/RNA损伤,过氧化氢酶和一氧化氮(NO)在组间显示显著p<0.001。ED标记物与血脂谱标记物的Spearman相关性显示维生素C水平与HDL-C呈正相关(p<0.001),与葡萄糖呈负相关(p<0.001)。各组间ICAM-1与HDL-C(p<0.01)、ApoA(p<0.001)呈显著负相关,与TG(p<0.01)、HbA1c(p<0.001)呈显著正相关。ED标志物与炎症/氧化应激生物标志物的Spearman相关性显示维生素C水平与铁蛋白呈负相关(p<0.001),NO(p<0.001),GGT(p<0.001),和ALT(p<0.001)水平。ICAM-1与hs-CRP呈显著正相关(p<0.01)。IL-6(p<0.001),TNF-α(p<0.01),GGT(p<0.05),两组的ALT(p<0.05)。
■这项研究揭示了血脂异常的生物标志物之间的紧密联系,炎症,和氧化应激与超重/肥胖患者的ED。这项研究可能用于预测该人群未来的心血管事件。
UNASSIGNED: The United Arab Emirates (UAE), with its characteristic local population, geography, and history, presents several risk factors for cardiovascular diseases (CVDs) in obese individuals. Obesity and its associated complications, including diabetes, atherogenic dyslipidemia, and CVDs leading to significant health risks. In the present
study, \"Youths\" defined as young people between 18 and 22 years. We assessed dyslipidemia, inflammation, and oxidative stress biomarker levels and their association with endothelial dysfunction (ED) in both overweight/obese and normal weight youths of UAE.
UNASSIGNED: There were 160 youths with overweight/obese (BMI ≥ 25 kg/m2) patients and healthy age- and sex-matched normal weight (BMI ≤ 24.9 kg/m2) as controls participated in this
study. The anthropometric data and blood samples were collected to assess the biomarkers for dyslipidemia, inflammation, oxidative stress, ED from all the youths.
UNASSIGNED: The overall mean age and male-to-female ratio were 20±1.5years and 1.0:1.2, respectively. There was statistically significant difference in HDL-C (p<0.001), triglycerides (TG) (p<0.001), ApoA (p=0.002), ApoB/ApoA ratio (p=0.009) between the overweight/obese and normal weight youths. Among, inflammatory markers: hs-CRP, IL-6, TNF-α also showed significant p<0.001 and oxidative stress markers: DNA/RNA Damage, catalase and nitric oxide (NO) showed significant p<0.001 between groups. Spearman correlation of ED markers with lipid profile markers showed Vitamin C levels positively correlated with HDL-C (p<0.001) and negatively correlated with glucose (p<0.001). ICAM-1showed significant negative correlation with HDL-C (p<0.01) and ApoA (p<0.001) but positive correlation with TG (p<0.01) and HbA1c (p<0.001) among groups. Spearman correlation of ED markers with inflammatory/oxidative stress biomarkers showed Vitamin C levels negatively correlated with ferritin (p < 0.001), NO (p < 0.001), GGT (p < 0.001), and ALT (p < 0.001) levels. The ICAM-1showed significant positive correlation with hs-CRP (p < 0.01), IL-6 (p < 0.001), TNF-α (p < 0.01), GGT (p < 0.05), and ALT (p < 0.05) in both groups.
UNASSIGNED: This
study revealed a strong link between the biomarkers of dyslipidemia, inflammation, and oxidative stress with ED in overweight/obese patients. This
study might be used to predict future cardiovascular events in this population.