背景:餐后血脂(PPL)与内皮功能障碍(ED)的风险增加有关,动脉粥样硬化性心血管疾病(ASCVD)的前兆。低碳水化合物的影响,高脂肪(LCHF)饮食对ASCVD风险的影响是不确定的;因此,更好地了解PPL上的LCHF膳食可能会提供有价值的见解。
目的:目前的系统评价研究了单餐LCHF对PPL和ED标志物的影响。
方法:CINAHLPlus,PubMed,WebofScience,和Cochrane中央对照试验注册中心(CENTRAL)搜索与内皮功能相关的关键术语,心血管疾病,血糖,血脂血症,和餐后状态,没有日期限制。
方法:全文由2名审稿人独立筛选,其中16项研究符合纳入本次审查的资格.所有试验都报道了在食用LCHF餐后对餐后甘油三酯(PPTG)的最低分析(<26%的能量作为碳水化合物)。结果根据系统评价和荟萃分析的首选报告项目(PRISMA)声明进行报告。
方法:发现单餐大量营养素组成在确定餐后8小时内的餐后脂质和脂蛋白反应中起关键作用。食用LCHF膳食会增加PPTG,并可能通过减少流量介导的扩张和增加的氧化应激而导致ED;然而,能量和大量营养素组成在研究之间差异很大。
结论:LCHF膳食的消费对PPL有负面影响,但不是全部,单餐研究;因此,LCHF膳食对心脏代谢健康结局的贡献尚不清楚.需要对特定类别的LCHF饮食进行进一步研究,以建立餐后脂质/脂蛋白调节与血管内皮功能受损之间的因果关系。
背景:PROSPERO注册号。CRD42023398774。
BACKGROUND: Postprandial lipemia (PPL) is associated with increased risk of endothelial dysfunction (ED), a precursor of atherosclerotic cardiovascular disease (ASCVD). The effects of low-carbohydrate, high-fat (LCHF) diets on ASCVD risk are uncertain; therefore, gaining a greater understanding of LCHF meals on PPL may provide valuable insights.
OBJECTIVE: The current systematic
review investigated the effects of single LCHF meal consumption on PPL and markers of ED.
METHODS: CINAHL Plus, PubMed, Web of Science, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched for key terms related to endothelial function, cardiovascular disease, glycemia, lipemia, and the postprandial state with no restriction on date.
METHODS: Full-text articles were independently screened by 2 reviewers, of which 16 studies were eligible to be included in the current
review. All trials reported a minimum analysis of postprandial triglycerides (PPTG) following consumption of an LCHF meal (<26% of energy as carbohydrate). Results were reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.
METHODS: Single-meal macronutrient composition was found to play a key role in determining postprandial lipid and lipoprotein responses up to 8 hours post-meal. Consumption of LCHF meals increased PPTG and may contribute to ED via reduced flow-mediated dilation and increased oxidative stress; however, energy and macronutrient composition varied considerably between studies.
CONCLUSIONS: Consumption of an LCHF meal had a negative impact on PPL based on some, but not all, single-meal studies; therefore, the contribution of LCHF meals to cardiometabolic health outcomes remains unclear. Further research is needed on specific categories of LCHF diets to establish a causal relationship between postprandial modulation of lipids/lipoproteins and impaired vascular endothelial function.
BACKGROUND: PROSPERO registration no. CRD 42023398774.