Microplastics are emerging sources of environmental pollutants that are increasingly of concern because of their harmful impacts on aquatic life and thereby humans. Their accumulation in the environment is in direct proportion to global plastic production; their being nondegradable, recalcitrant and of a persistent nature creates an urgent need to address this issue on a global scale. Recent reports have demonstrated the presence of microplastics in marine life, and directly becoming a part of the food chain when seafood is ingested by humans. The repercussions of these studies point to an even larger scale presence of microplastics across varied habitats, which are yet to be sampled. Bioremediation, using various microorganisms such as bacteria, algae and fungi, alone or as consortia or in biofilm form can be used as an effective remediation tool. Genetically modified microorganisms for focused removal of microplastics and metagenomics studies, providing taxonomic details of uncultured organisms, are also expected to provide an additional catalogue of technologies in this field. This review offers a comprehensive overview of microplastic sources, existing technologies for treating microplastics and an in-depth analysis of bioremediation mechanisms, its components, and the results from various studies which provide sufficient clues as to the directions to be chosen to address microplastics pollution and can facilitate and instruct researchers to further investigate the more practical approaches and create new and innovative strategies for advanced remediation of microplastic in the future.

The European Medicines Agency (EMA) mandates Environmental Risk Assessments (ERAs) since 2006 to determine potential risks of new marketed medicines. Drugs with a Predicted Environmental Concentration (PEC) in inland surface waters exceeding 0.01 μg L-1 require further environmental risk assessment. PEC may be refined based on prevalence data and/or based on the treatment regimen. In this study, based on EMA regulations, refined PEC of 108 antineoplastic drugs in coastal waters were determined based on the consumption in a coastal health area during 2021, identifying six drugs with potential environmental risk in surface waters (hydroxyurea, capecitabine, abiraterone, ibrutinib, imatinib and 5-fluorouracil) and two in marine ecosystem (hydroxyurea and capecitabine). Comparison of these refined PECs with data from marketing laboratories revealed significant disparities, suggesting the need for regular updates, especially with changes in drug indications or financing. Notably, the identified drugs are not yet on the main reference lists of emerging contaminants.

Sediment cores are optimal mediums for investigating the historical presence of offshore microplastics (MPs). In this study, two sediment cores were collected at varying water depths, i.e., XS2 (10 m) and XS3 (20 m), from the Xiangshan offshore (XSO) in Ningbo. We focused on the spatiotemporal distribution characteristics of MPs within two sediment cores and explored the response differences of MPs abundance to natural factors and human activities. The results showed that the MPs abundance in sediments has gradually increased since the late 1960s, but with interannual fluctuations. MPs abundance in XS2 and XS3 were 1133-8700 and 633-11433 items/kg dry weight, respectively. The predominant polymers were PA, PU, PET and ACR, with fragmented particles being the most prevalent shape of MPs. The MPs abundance in XS2 and XS3 had a similar response to natural factors, mainly including (i) MPs abundance significantly correlated with the sediment load of the Qiantang River (p < 0.01), indicating that sediment load might be an important factor affecting the MPs abundance and that MPs transported by rivers had characteristics of near-source sedimentation; (ii) typhoons had the effect of weakening the MPs abundance; and (iii) geological activities might be potential contributing factors to variations in MPs\' abundance in deep sediments. Correlation analyses demonstrated that MPs in XSO was the result of multiple sources, stemming from plastic production, sewage discharge, marine fisheries and shipping activities. Notably, XS3 exhibited higher sensitivity to human activities compared to XS2, owing to differences in sampling locations. This study underscores the significance of employing two sediment cores, rather than a single core, as it provides a more comprehensive insight into the overarching trends and disparities in the historical pollution of MPs. Our findings contribute to a deeper understanding of the history of offshore MPs pollution, shedding new light on this critical environmental issue.

This study evaluated the occurrence and distribution of largely known pollutants (Ag, Cd, Cu, Cr, Hg, Ni, Pb, Pd, and Zn), as well as emerging ones (Li, and V) in the water dissolved fraction, suspended particulate matter, and surface sediments from the lower course of the Negro River, Argentina. There are scarce preceding data on inorganic pollution in the entire watershed and, in the case of the emerging pollutants, there are almost no studies performed worldwide. Sampling was conducted in 2019 at six sampling sites, three of them mostly river dominated and the rest under marine domain. The samples were subjected to an acid digestion in a microwave digester, and analyzed using an Inductively Coupled Plasma Atomic Emission Spectrometer. Results: revealed that Cu, Li, V, and Zn were always on the top four of the highest average metal concentrations in water and sediment fractions. The pollution assessment indicated that the watershed might be exposed to anthropogenic pollution, as over 60% of Cu and Zn, and over 85% of Hg in water dissolved samples from the marine dominated sites were above the maximum recommended values from guidelines. The multivariate analyses characterized the watershed into two clusters, with metals in the sediment fraction mainly contributing to the uppermost sites. Indeed, sedimentary Cu and Zn background enrichment indices pointed out a moderate pollution of the river dominated sites. This study highlights the relevance of an integrative approach in metal pollution evaluation, as the results denoted a progressive deterioration of the watershed, affecting the water quality of the lower course of the Negro River and its adjacent coastal zone. Overall, these results contribute to a more complete evaluation of the potential to fulfill the Sustainable Development Goals, with implications for future treatment strategies to enhance the environmental quality of the area.

This study aims to investigate the distribution and ecological risk assessment of microplastics (MPs) in peatland areas located in Long An province, Vietnam\'s Mekong Delta. In general, polyvinyl chloride (60.7%), polyethylene (25.8%), and polypropylene (11.9%) were the most abundant polymers determined in the thirty sediment samples. The hazard index (HI) remarked a level of III for MPs contamination in Tan Thanh and Thanh Hoa districts. The pollution load index (PLI) and potential ecological risk index (RI) indicated that the contamination risk of MPs polymer types in the studied sites is relatively high. According to PLI values, MPs levels of peatlands in Tan Thanh and Thanh Hoa are high and moderate, respectively, while the peatland sediments in Duc Hue district are less contaminated. Furthermore, ecological risk indexes in the peatland areas were relatively high, with PLIoverall (level III); HIoverall (level V), and RIoverall (extreme danger). Hence, this study proposed a SWOT framework for challenges of MPs pollution in order to manage peatlands appropriately and minimize ecological risks. As a result, several practical strategies and appropriate approaches have been recommended to reduce microplastics towards a circular economy. These findings provide the initial quantitative assessment insights into hazard levels and ecological impacts of MPs in Vietnam\'s Mekong Delta peatlands.

Precision biotransformation is an envisioned strategy offering detailed insights into biotransformation pathways in real environmental settings using experimentally guided high-accuracy quantum chemistry. Emerging pollutants, whose metabolites are easily overlooked but may cause idiosyncratic toxicity, are important targets of such a strategy. We demonstrate here that complex metabolic reactions of tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) catalyzed by human CYP450 enzymes can be mapped via a three-step synergy strategy: (i) screening the possible metabolites via high-throughout (moderate-accuracy) computations; (ii) analyzing the proposed metabolites in vitro by human liver microsomes and recombinant human CYP450 enzymes; and (iii) rationalizing the experimental data via precise mechanisms using high-level targeted computations. Through the bilateral dialogues from qualitative to semi-quantitative to quantitative levels, we show how TDCIPP metabolism especially by CYP3A4 generates bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) as an O-dealkylation metabolite and bis(1,3-dichloro-2-propyl) 3-chloro-1-hydroxy-2-propyl phosphate (alcoholβ-dehalogen) as a dehalogenation/reduction metabolite via the initial rate-determining H-abstraction from αC- and βC-positions. The relative yield ratio [dehalogenation/reduction]/[O-dealkylation] is derived from the relative barriers of H-abstraction at the βC- and αC-positions by CYP3A4, estimated as 0.002 to 0.23, viz., an in vitro measured ratio of 0.04. Importantly, alcoholβ-dehalogen formation points to a new mechanism involving successive oxidation and reduction functions of CYP450, with its precursor aldehydeβ-dehalogen being a key intermediate detected by trapping assays and rationalized by computations. We conclude that the proposed three-step synergy strategy may meet the increasing challenge of elucidating biotransformation mechanisms of substantial synthesized organic compounds in the future.

Due to the negative effects of emerging contaminants on the environment, that can potentially induce deleterious effects in aquatic and human life, this paper focuses on the removal from the water of Furosemide, through the adsorption process. Indeed, only a few papers are available in the literature about the Furosemide adsorption and, chitosan films are thus proposed for this purpose as safe, sustainable, and recyclable adsorbent materials. In the present work, the effects on the adsorption process of several experimental parameters such as the pH values, ionic strength, amount of adsorbent/pollutant, and temperature values were investigated. The kinetics models, isotherms of adsorption, and the thermodynamic parameters were studied showing that the Furosemide physisorption occurred on the heterogeneous Chitosan surface, endothermically (ΔH° = +31.27 ± 3.40 kJ mol-1) and spontaneously (ΔS° = +150.00 ± 10.00 J mol-1 K-1), following a pseudo-second-order kinetic model. The 90% of the pollutant was adsorbed in 2 h, with a maximum adsorption capacity of 3.5 mg × g-1. Despite these relatively low adsorption capacities, experiments of desorption were performed and 100% of adsorbed Furosemide was recovered by using concentrated NaCl solutions, proposing a low-cost and green approach, with respect to the previous literature relative to the Furosemide adsorption, fundamental for the pollutant recovery and adsorbent reuse.

This work proposes new eco-materials for the adsorption of diclofenac (DCF). The large consumption of this nonsteroidal anti-inflammatory drug combined with the inefficiency of wastewater treatment plants (WWTPs) leads to its presence in aquatic environments as an emerging pollutant. The adsorption technique is widely used for pharmaceutical removal. Moreover, due to the large effect of commercial adsorbents, in the frame of the Azure Chemistry approach, new sustainable materials are mandatory for removal as emerging pollutants. The work proposes three adsorbents that were obtained from different stabilization methods of fly ash derived from an incinerator plant; the stabilization techniques involved the use of various industrial by-products such as bottom ash, flue gas desulphurization residues, coal fly ash, and silica fume. The best performance, although less than activated carbon, was obtained by COSMOS (COlloidal Silica Medium to Obtain Safe inert: the case of incinerator fly ash), with a removal efficacy of approximately 76% with 15 g/L of material. Several advantages are expected not only from the DCF removal but also from an economic perspective (the newly obtained adsorbents are eco-materials, so they are cheaper in comparison to conventional adsorbents) and in terms of sustainability (no toxic reagents and no heating treatment are involved). This work highlights the adsorption performance of the new eco-materials and their potential use in WWTPs.

Emerging contaminants (EPs) represent a significant risk to human, ecological and environmental health. Although progress has been made in establishing monitoring in environmental matrices, health effects, legislation and control, there are still problems associated with regional bias and the types of EPs commonly assessed, which may underestimate the risk to health. In Latin America there are limited reports on environmental monitoring of EPs and it is generally focused on wastewater. This review identifies the current research deficiencies for emerging contaminants in the Latin American region, and we address the case of nonylphenol as an under-studied EP in the region. Nonylphenol is a degradation product of nonylphenol ethoxylate, which is a surfactant widely used in the manufacture of detergents in Latin America, environmental concentrations have been reported, predominantly in water, and the possible effects on species in this region have been also described. The importance of the review of this compound in the region lies in the fact that the Rotterdam Convention has catalogued nonylphenol as a severely restricted compound, so it is necessary to establish measures for its restriction and change to a sustainable technology. Finally, the example of NP presented in this review highlights the lack of regulation in Latin America regarding to EPs, resulting in the contamination of wastewater, effluents, rivers and drinking water. It is imperative to determine the potential effects, occurrence and concentration levels to improve the regulation of these pollutants in a timely manner.

BACKGROUND: The aim of this study was to characterize solid particulate aerosol derived from a cutlery microenterprise and to investigate substances associated with activities performed within the work environment.
OBJECTIVE: Suspended particulate matter (SPM) was collected at different locations in the cutlery workshop and near machines used by workers, using passive sampling devices fitted with polytetrafluoroethylene filters, onto which total particulate material was deposited. The substances present in the SPM were analyzed using gas chromatography-mass spectrometry (GC-MS).
RESULTS: Identification of the substances was performed using the National Institute of Standards (NIST) library and automated mass spectral deconvolution and identification system. (AMDIS) software, considering at least 70% probability. The concentration of total dust, obtained using a gravimetric method, was approximately 1 mg.m-3.
CONCLUSIONS: The toxic substances found in the SPM included halogenated hydrocarbons (containing chlorine, fluorine, and iodine) and aromatic hydrocarbons. The toxic substances included naphthalene, which is classified as carcinogenic.