Per- and polyfluoroalkyl substances (PFASs) have garnered considerable scientific and regulatory scrutiny due to their widespread distribution across environments and their potential toxicological impacts on human health. The pedosphere serves as a vital reservoir for these chemicals, significantly determining their environmental trajectory and chemical transformations. This study offers a comprehensive synthesis of the current understanding regarding the adsorption mechanics of PFASs in soil matrices. Due to their unique molecular structure, PFASs predominantly engage in hydrophobic and electrostatic interactions during soil adsorption. This work thoroughly evaluates the influence of various factors on adsorption efficiency, including soil properties, molecular characteristics of PFASs, and the prevailing environmental conditions. The complex nature of soil environments complicates isolating individual impacts on PFAS behavior, necessitating an integrated approach to understanding their environmental destinies better. Through this exploration, we seek to clarify the complex interplay of factors that modulate the adsorption of PFASs in soils, highlighting the urgent need for future research to disentangle the intricate and combined effects that control the environmental behavior of PFAS compounds.

With the COVID-19 pandemic continuing, more contagious SARS-CoV-2 variants, including Omicron, have been emerging. The mutations, especially those that occurred on the spike (S) protein receptor-binding domain (RBD), are of significant concern due to their potential capacity to increase viral infectivity, virulence, and breakthrough antibodies\' protection. However, the molecular mechanism involved in the pathophysiological change of SARS-CoV-2 mutations remains poorly understood. Here, we summarized 21 RBD mutations and their human angiotensin-converting enzyme 2 (hACE2) and/or neutralizing antibodies\' binding characteristics. We found that most RBD mutations, which could increase surface positive charge or polarity, enhanced their hACE2 binding affinity and immune evasion. Based on the dependence of electrostatic interaction of the epitope residue of virus and docking protein (like virus receptors or antibodies) for its invasion, we postulated that the charge and/or polarity changes of novel mutations on the RBD domain of S protein could affect its affinity for the hACE2 and antibodies. Thus, we modeled mutant S trimers and RBD-hACE2 complexes and calculated their electrotactic distribution to study surface charge changes. Meanwhile, we emphasized that heparan sulfate proteoglycans (HSPGs) might play an important role in the hACE2-mediated entry of SARS-CoV-2 into cells. Those hypotheses provide some hints on how SARS-CoV-2 mutations enhance viral fitness and immune evasion, which may indicate potential ways for drug design, next-generation vaccine development, and antibody therapies.

Microplastics (MPs) have been defined as particles of size < 5 mm and are characterized by hydrophobicity and large surface areas. MPs interact with co-occurring hydrophobic organic contaminants (HOCs) via sorption-desorption processes in aquatic and terrestrial environments. Ingestion of MPs by living organisms may increase exposure to HOC levels. The key mechanisms for the sorption of HOCs onto MPs are hydrophobic interaction, electrostatic interaction, π-π interactions, hydrogen bonding, and Van der Waals forces (vdW). Polymer type, UV-light-induced surface modifications, and the formation of oxygen-containing functional groups have a greater influence on electrostatic and hydrogen bonding interactions. In contrast, the formation of oxygen-containing functional groups negatively influences hydrophobic interaction. MP characteristics such as crystallinity, weathering, and surface morphology affect sorption capacity. Matrix properties such as pH, ionic strength, and dissolved organic matter (DOM) also influence sorption capacity by exerting synergistic/antagonistic effects. We reviewed the mechanisms of HOC sorption onto MPs and the polymer and matrix properties that influence the HOC sorption. Knowledge gaps and future research directions are outlined.

The review article is dedicated to a comprehensive study of the chemical bond formed during the immobilization of the proteolytic enzyme pancreatic trypsin in chitosan-based polymer matrixes and its derivatives. The main focus of the study is to describe the chemical bond that causes immobilization between chitosan based carriers and trypsin. Because the nature of the chemical bond between the carrier and trypsin is a key factor in determining the area of application of the conjugate. It has been found out that after the chemical nature of functional groups, their degree of ionization, the structure of the chemical cross-linking, the medium pH and ionic strength of chitosan are modified, the mechanism of trypsin immobilization is affected. As a result, the attraction enzyme to the matrix occurs due to polar covalent and hydrogen bonds, as well as electrostatic, hydrophobic, Van der Waals forces. The collected research works on the immobilization of trypsin on chitosan-based carriers have been systematized in the paper and shown schematically in subsystems according to the type of chemical interaction. It has been shown that the immobilization of trypsin on chitosan based matrixes occur more often due to the covalent and hydrogen bonds between the protein and the carrier.

Egg white protein (EWP) was one of the high-quality protein sources and widely used in the food industries because of excellent emulsifying, gelling, and foaming properties. Polysaccharides as a natural biological macromolecule have been used to improve the functional properties of EWP. The electrostatic interaction was the main driving force between EWP and polysaccharides. However, protein-polysaccharides complexes were susceptible to environmental factors including pH, ionic strength, polymer ratio, and temperature. In this paper, the functional properties of EWP were summarized. More importantly, the effects of polysaccharides on the functional properties of EWP were highlighted and reviewed referring to emulsifying, foaming, and gelling properties. The impact of environmental factors on the protein-polysaccharides interaction were also discussed. This paper leaded to enrich research systems of protein-polysaccharides interaction and provided information for the development of new egg white-derived foods.

Polyphenol-based materials are of wide-spread interest because of the unique properties of the polyphenol itself. Tannic acid, contains high level of galloyl groups, could be coordinated to a range of metal ions to generate robust mental ion-TA films on substrate or even forming hollow capsules. These films or capsules can be used in the field of sensing, separation and catalysis, most importantly in drug/nutraceutical delivery, allowing for the high loading efficiency, high mechanical and thermal stability, pH-responsive disassembly and fluorescence behavior. Additionally, such coating could also provide protection of the sensitive molecules and cells. With the numerous carbonyl and phenolic functional groups, TA has also been demonstrated to form strong hydrogen bonded multilayers with various non-ionic polymers. The properties of the hydrogen-bonded system were highly influenced by the chemical structure of the polymers, which will change the behavior of pH-, temperature- or ionic strength-responsive release of the loading molecules. Additionally, the ionization of galloyl phenol group was attributed to the interaction between TA and other ionic polymers by electrostatic interaction. The electrostatic interaction/hydrogen bonding derived TA/polyme$$%r complexes could deposit on glass slides, microcores or even forming hollow capsules, promising in their applicability to nutraceutical encapsulation, delivery and depot. Notably, polyphenols self-polymerizing could also deposit coatings on different substrates without any exogenous additives, while the comprehensive undertanding about the self-polymerizing mechenism remains unclear. This review provides a promising prospect for utilizing polyphenol-based materials to design versatile architecture in different system, used in the field of chemistry and materials science.

Perfluorinated compounds (PFCs) have drawn great attention recently due to their wide distribution in aquatic environments and potential toxic to animals and human beings. Adsorption not only is an effective technology to remove PFCs from water or wastewater, but also affects PFC distribution at solid-liquid interfaces and their fate in aquatic environments. This article reviews the adsorption behavior of different PFCs (mainly perfluorooctane sulfonate and perfluorooctanoate) on various adsorptive materials. Some effective adsorbents are introduced in detail in terms of their preparation, characteristics, effects of solution chemistry and PFC properties on adsorption. Adsorption mechanisms of PFCs on different adsorbents are summarized, and various interactions including electrostatic interaction, hydrophobic interaction, ligand exchange, and hydrogen bond are fully reviewed. The adsorbents with amine groups generally have high adsorption capacity for PFCs, and formation of micelles/hemi-micelles plays an important role in achieving high adsorption capacity of perfluorinated surfactants on some porous adsorbents. Hydrophobic interaction is mainly responsible for PFC adsorption, but the difference between PFCs and traditional hydrocarbons has not clearly clarified. This review paper would be helpful for the preparation of effective adsorbents for PFC removal and understanding interfacial process of PFCs during their transport and fate in aquatic environments.

Over the past several years, great advances have been made towards novel drug delivery systems. The phenomena of interpolymer interactions and formation of polyelectrolyte complexes have been the focus of intensive fundamental and applied research. Interpolyelectrolyte complexes combine unique physicochemical properties with high biocompatibility. Studies have been carried out on many different polymer blends and types. Such combinations may possess unique properties that are different from those of individual component. The present review emphasizes on the applicability of polyelectrolyte complexes in drug delivery technology.