背景:广泛性关节过度活动(GJH)可能是几种遗传性结缔组织疾病的结果,尤其是Ehlers-Danlos综合征.脑血管表现是该疾病最常见的并发症之一,了解其程度可以帮助更好地诊断和预防危险事件。我们调查了GJH患者的视觉诱发电位(VEP)变化,并将其与健康人进行了比较。
方法:我们的病例对照研究包括90名符合关节活动过度的Beighton评分(B评分)的患者和其他90名健康参与者。他们都接受了VEP研究,并比较了诱发电位(P100)的幅度和潜伏期。
结果:病例组B评分明显较高(7.18±0.967vs.1.18±0.712),P100延迟(110.23±6.64msvs.100.18±4.273ms),和振幅(6.54±1.26mvvs.6.50±1.29mv)与对照组相比,但差异仅在B评分方面显着,和P100延迟(p值<.0001)。此外,P100的潜伏期和波幅均与病例组的B评分呈显著正相关(p值<.0001),但在对照组中没有发现这种相关性(p值=.059)。
结论:我们的研究可以揭示VEP的变化,在以前没有神经系统或肌肉骨骼疾病的GJH患者中,P100潜伏期尤其明显。无论这些变化是由于GJH本身还是不可避免的神经系统疾病或视觉通路参与的预测,尤其是多发性硬化症需要进一步研究,随访时间更长.
BACKGROUND: Generalized joint hypermobility (GJH) can be the result of several hereditary connective tissue disorders, especially Ehlers-Danlos syndrome. Cerebrovascular manifestations are among the most common complications in this disorder, and understanding their extent can help better diagnosis and prevention of hazardous events. We investigated visual evoked potential (VEP) changes in patients with GJH and compared them with healthy individuals.
METHODS: Our
case-control study included 90 patients who fulfilled the Beighton score (B score) for joint hypermobility and other 90 healthy participants. All of them went under VEP study, and the amplitude and latency of the evoked potential (P100) were compared to each other.
RESULTS: The
Case group had significantly higher B score (7.18 ± 0.967 vs. 1.18 ± 0.712), P100 latency (110.23 ± 6.64 ms vs. 100.18 ± 4.273 ms), and amplitude (6.54 ± 1.26 mv vs. 6.50 ± 1.29 mv) compared with the Control group, but the difference was only significant regarding B score, and P100 latency (p-value <.0001). Moreover, both latency and amplitude of P100 had significantly positive correlations with the B score in the
Case group (p-value <.0001), but such correlations were not found in the Control group (p-value = .059).
CONCLUSIONS: Our study could reveal VEP changes, especially significant P100 latency in GJH patients without previous neurologic or musculoskeletal disorders. Whether these changes are due to GJH itself or are predictive of inevitable neurologic disease or visual pathway involvement, particularly Multiple Sclerosis needs further investigation with longer follow-up periods.