Abstract：
Hereditary connective tissue disorders are a broad group of congenital disorders that are characterized by a pathological weakness of the connective tissue as a result of an incorrect genesis, leading to multisystem complaints. We describe a 14-year-old patient with the hereditary connective tissue disorder Loeys-Dietz syndrome who was admitted to a child psychiatric crisis unit because of depressive and anxiety symptoms. A systematic literature search was carried out to analyze the prevalence of depressive and anxiety symptoms in individuals with hereditary connective tissue disorders Loeys-Dietz syndrome, Ehlers-Danlos syndrome and Marfan syndrome, to identify a possible association between these disorders and explanations for this. We conclude that there is an increased incidence of depression and anxiety symptoms in which pain, fatigue, social support and functioning, quality of life and functional limitations seem to play a role. There is a need for further research to determine exactly which factors contribute and how these can be targeted in prevention and treatment.
摘要：
遗传性结缔组织疾病是一组广泛的先天性疾病，其特征是由于不正确的起源而导致结缔组织的病理性虚弱。导致多系统投诉。我们描述了一名14岁的遗传性结缔组织疾病Loeys-Dietz综合征患者，该患者因抑郁和焦虑症状而被送入儿童精神危机病房。进行了系统的文献检索，以分析患有遗传性结缔组织疾病Loeys-Dietz综合征的个体中抑郁和焦虑症状的患病率，Ehlers-Danlos综合征和Marfan综合征,以确定这些疾病之间可能的关联和对此的解释。我们得出的结论是，抑郁和焦虑症状的发生率增加，其中疼痛，疲劳,社会支持和功能，生活质量和功能限制似乎起作用。需要进行进一步的研究，以确切地确定哪些因素以及如何将这些因素作为预防和治疗的目标。
