■先前基于静息态功能磁共振成像(rs-fMRI)和基于体素的形态计量学(VBM)的研究表明,早发性精神分裂症(EOS)患者的大脑结构和静息态功能大脑活动明显异常,与健康对照(HCs)相比,这些改变与EOS的发病机制密切相关。然而,以前的研究受到小样本量和结果高度异质性的限制。因此,本研究旨在有效整合以往的研究,以确定EOS患者常见和特定的脑功能和结构异常。
■PubMed,WebofScience,Embase,中国国家知识基础设施(CNKI),系统搜索了WanFang数据库,以确定有关EOS患者静息状态区域功能脑活动和灰质体积(GMV)异常的出版物。然后,我们利用基于种子的d映射与受试者图像排列(SDM-PSI)软件进行VBM和rs-fMRI研究的全脑体素荟萃分析,分别,并在此基础上进行多模态重叠,全面识别EOS患者的脑结构和功能异常。
■本荟萃分析共纳入了27项原始研究(28个数据集),包括与静息状态功能性脑活动相关的12项研究(13个数据集)(496名EOS患者,395项HCs)和15项与GMV相关的研究(15项数据集)(458例EOS患者,531HC)。总的来说,在功能荟萃分析中,EOS患者在左额中回(延伸至左额下回的三角形部分)和右尾状核中显示出静息状态的功能性脑活动显着增加。另一方面,在结构荟萃分析中,EOS患者在右颞上回(延伸到右罗兰骨)显示GMV显着降低,右颞中回,和颞极(颞上回)。
■这项荟萃分析显示,EOS中的某些区域表现出明显的结构或功能异常,比如时间回转,前额叶皮质,和纹状体。这些发现可能有助于加深我们对EOS潜在病理生理机制的理解,并为EOS的诊断或治疗提供潜在的生物标志物。
UNASSIGNED: Previous studies based on resting-state functional magnetic resonance imaging(rs-fMRI) and voxel-based morphometry (VBM) have demonstrated significant abnormalities in brain structure and resting-state functional brain activity in patients with early-onset schizophrenia (EOS), compared with healthy controls (HCs), and these alterations were closely related to the pathogenesis of EOS. However, previous studies suffer from the limitations of small sample sizes and high heterogeneity of results. Therefore, the present study aimed to effectively integrate previous studies to identify common and specific brain functional and structural abnormalities in patients with EOS.
UNASSIGNED: The PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure (CNKI), and WanFang databases were systematically searched to identify publications on abnormalities in resting-state regional functional brain activity and gray matter volume (GMV) in patients with EOS. Then, we utilized the Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) software to conduct a whole-brain voxel meta-analysis of VBM and rs-fMRI studies, respectively, and followed by multimodal overlapping on this basis to comprehensively identify brain structural and functional abnormalities in patients with EOS.
UNASSIGNED: A total of 27 original studies (28 datasets) were included in the present meta-analysis, including 12 studies (13 datasets) related to resting-state functional brain activity (496 EOS patients, 395 HCs) and 15 studies (15 datasets) related to GMV (458 EOS patients, 531 HCs). Overall, in the functional meta-analysis, patients with EOS showed significantly increased resting-state functional brain activity in the left middle frontal gyrus (extending to the triangular part of the left inferior frontal gyrus) and the right caudate nucleus. On the other hand, in the structural meta-analysis, patients with EOS showed significantly decreased GMV in the right superior temporal gyrus (extending to the right rolandic operculum), the right middle temporal gyrus, and the temporal pole (superior temporal gyrus).
UNASSIGNED: This meta-analysis revealed that some regions in the EOS exhibited significant structural or functional abnormalities, such as the temporal gyri, prefrontal cortex, and striatum. These findings may help deepen our understanding of the underlying pathophysiological mechanisms of EOS and provide potential biomarkers for the diagnosis or treatment of EOS.