Abstract：
UNASSIGNED: Lifetime co-occurring substance use disorders are common at the time of presentation for the treatment of primary psychosis. Our aim was to investigate the clinical characteristics of adolescents with early-onset schizophrenia/schizoaffective disorder (EOS), categorized as either with (EOS + SUD) or without SUD (non-SUD/EOS), in a multi-center sample.
UNASSIGNED: Between 2016 and 2022, 255 patients were evaluated across three tertiary-care inpatient units. Diagnoses were confirmed by the treating physician according to the DSM-5 during the hospital stay. The severity of symptoms was measured using the Positive and Negative Syndrome Scale (PANSS).
UNASSIGNED: The EOS + SUD group exhibited a higher illness onset, fewer years of education, longer duration of untreated psychosis (DUP), a higher frequency of male gender, more frequent hospitalizations, increased use of clozapine and zuclopenthixol LAI, along with higher rates of post-traumatic stress disorder and conduct disorder. Notably, differences in DUP, clozapine use, and the number of hospitalizations did not persist in the multivariate logistic regression model.
UNASSIGNED: Our findings support the notion of SUD playing a role in modifying the course of illness in EOS. Future studies should emphasize exploring treatment responses to medications and interventions among youth with dual diagnoses.
UNASSIGNED: Between 2016 and 2022, 255 patients were evaluated across three tertiary-care inpatient units. Diagnoses were confirmed by the treating physician according to the DSM-5 during the hospital stay. The severity of symptoms was measured using the Positive and Negative Syndrome Scale (PANSS).
UNASSIGNED: The EOS + SUD group exhibited a higher illness onset, fewer years of education, longer duration of untreated psychosis (DUP), a higher frequency of male gender, more frequent hospitalizations, increased use of clozapine and zuclopenthixol LAI, along with higher rates of post-traumatic stress disorder and conduct disorder. Notably, differences in DUP, clozapine use, and the number of hospitalizations did not persist in the multivariate logistic regression model.
UNASSIGNED: Our findings support the notion of SUD playing a role in modifying the course of illness in EOS. Future studies should emphasize exploring treatment responses to medications and interventions among youth with dual diagnoses.
摘要：
■终生同时发生的物质使用障碍在治疗原发性精神病时很常见。我们的目的是调查青少年早发性精神分裂症/分裂情感障碍（EOS）的临床特征，分类为带(EOS+SUD)或不带SUD(非SUD/EOS)，在多中心样本中。
■在2016年至2022年之间，对三个三级护理住院单位的255名患者进行了评估。在住院期间由治疗医师根据DSM-5确认诊断。使用阳性和阴性综合征量表（PANSS）测量症状的严重程度。
■EOS+SUD组表现出更高的发病，少受教育的时间，未治疗精神病（DUP）的持续时间更长，男性的频率更高，更频繁的住院，增加使用氯氮平和唑氯戊索LAI，创伤后应激障碍和品行障碍的发生率更高。值得注意的是,DUP的差异，使用氯氮平,在多变量逻辑回归模型中,住院次数并不持续.
■我们的研究结果支持SUD在改变EOS的病程中发挥作用的概念。未来的研究应强调探索双重诊断的年轻人对药物和干预的治疗反应。
■在2016年至2022年之间，对三个三级护理住院单位的255名患者进行了评估。在住院期间由治疗医师根据DSM-5确认诊断。使用阳性和阴性综合征量表（PANSS）测量症状的严重程度。
■EOS+SUD组表现出更高的发病，少受教育的时间，未治疗精神病（DUP）的持续时间更长，男性的频率更高，更频繁的住院，增加使用氯氮平和唑氯戊索LAI，创伤后应激障碍和品行障碍的发生率更高。值得注意的是,DUP的差异，使用氯氮平,在多变量逻辑回归模型中,住院次数并不持续.
■我们的研究结果支持SUD在改变EOS的病程中发挥作用的概念。未来的研究应强调探索双重诊断的年轻人对药物和干预的治疗反应。
