%0 Journal Article
%T Illness-related outcomes of illicit substance use disorder in adolescents with early onset schizophrenia: a multicenter study.
%A Turan S
%A Ermiş Ç
%A Eray Ş
%A Ağaç N
%A Karakuş OB
%A Sağlam Y
%A Bandırma A
%A Güler D
%A Tunçtürk M
%A Çıray RO
%A Karaçetin G
%A İnal N
%A Üçok A
%J J Addict Dis
%V 0
%N 0
%D 2024 Apr 2
%M 38566305
%F 2.065
%R 10.1080/10550887.2024.2332512
%X <B>UNASSIGNED: </B>Lifetime co-occurring substance use disorders are common at the time of presentation for the treatment of primary psychosis. Our aim was to investigate the clinical characteristics of adolescents with early-onset schizophrenia/schizoaffective disorder (EOS), categorized as either with (EOS + SUD) or without SUD (non-SUD/EOS), in a multi-center sample.<BR><B>UNASSIGNED: </B>Between 2016 and 2022, 255 patients were evaluated across three tertiary-care inpatient units. Diagnoses were confirmed by the treating physician according to the DSM-5 during the hospital stay. The severity of symptoms was measured using the Positive and Negative Syndrome Scale (PANSS).<BR><B>UNASSIGNED: </B>The EOS + SUD group exhibited a higher illness onset, fewer years of education, longer duration of untreated psychosis (DUP), a higher frequency of male gender, more frequent hospitalizations, increased use of clozapine and zuclopenthixol LAI, along with higher rates of post-traumatic stress disorder and conduct disorder. Notably, differences in DUP, clozapine use, and the number of hospitalizations did not persist in the multivariate logistic regression model.<BR><B>UNASSIGNED: </B>Our findings support the notion of SUD playing a role in modifying the course of illness in EOS. Future studies should emphasize exploring treatment responses to medications and interventions among youth with dual diagnoses.