背景:适当的药物治疗对于患有急性应激障碍的飞行员非常重要。用药不当不仅会影响飞行员的身心健康,还会危及飞行安全。因此,我们旨在通过使用Delphi方法形成中国专家对飞行员急性应激障碍的药物治疗的共识,以快速有效地缓解症状并恢复认知功能。
方法:检索相关文献,列举飞行员急性应激障碍的药物治疗现状,然后根据调查情况采用德尔菲法进行两轮专家咨询和讨论。采用描述性统计方法对基本信息进行分析,权威系数,意见集中,和专家调查项目,就飞行员急性应激障碍的药物治疗达成共识。
结果:共有16位精神病学专家,药理学,邀请了来自中国不同省市的航空航天医学进行咨询。两轮会诊的回收率为100%,专家权威系数分别为0.897和0.906。各级指标的肯德尔一致性系数为0.564~0.594(p<0.01)。根据收到的票数,阿普唑仑片(16),右佐匹克隆片(15),和劳拉西泮片(14)被推荐用于治疗急性应激障碍的兴奋性精神运动症状;帕罗西汀片(15)和舍曲林片(15)可用于精神运动抑郁症状;奥氮平片(15),奥氮平口腔崩解片(14),并选择富马酸喹硫平片(14)治疗精神病症状。
结论:这项研究在快速有效的药物治疗急性应激障碍飞行员的不同症状方面达成了共识,为临床治疗提供参考。
Appropriate medication is very important for pilots with acute stress disorder. Improper medication can not only affect the physical and mental health of the pilots but can also endanger flight safety. Hence, we aimed to quickly and effectively relieve symptoms and restore cognitive function by forming a
consensus of Chinese experts on the pharmacological treatment of acute stress disorder in pilots using the Delphi method.
Relevant literature was searched to enumerate the current status of pharmacological treatment of acute stress disorder in pilots, followed by two rounds of expert consultation and discussion according to the listed status of the survey using the Delphi method. A descriptive statistical method was used to analyze the basic information, authority coefficients, concentration of opinions, and survey items of the experts to develop a
consensus on the pharmacological treatment of acute stress disorder in pilots.
A total of 16 experts in psychiatry, pharmacology, and aerospace medicine from different provinces and cities across China were invited for consultation. The recovery rate of the two rounds of consultation was 100%, and the expert authority coefficients were 0.897 and 0.906, respectively. Kendall\'s coefficient of concordance of indicators at all levels was 0.564-0.594 (p < 0.01). Based on the number of votes received, alprazolam tablets (16), eszopiclone tablets (15), and lorazepam tablets (14) were recommended for the treatment of excitatory psychomotor symptoms of acute stress disorder; paroxetine tablets (15) and sertraline tablets (15) were available for psychomotor depressive symptoms; olanzapine tablets (15), olanzapine orally disintegrating tablets (14), and quetiapine fumarate tablets (14) were selected for psychotic symptoms.
This study formed a
consensus on rapid and effective pharmacological treatment for different symptoms of acute stress disorder pilots, which provides a reference for clinical treatment.