该研究的目的是找到在OSCC患者中具有最大预后意义的临床和病理因素。分析包括125例患者,根据肿瘤原发部位(TPS)分组:口底(FOM),舌(TC)和磨牙后三角(RMT)。分级(G),肿瘤大小(pT),淋巴结转移(NM),局部复发(LR),淋巴结复发(NR),神经周浸润(PNI),淋巴管浸润(LVI),结外延伸(PENE),和节点产量(NY)在每组中进行评估。
■关于TPS,FOM似乎是最转移的。然而,复发率与TC肿瘤相似,其特征是G比其他地方高。分析G时,在G2患者中,LR(40.5%)和NM(34.5%)的百分比最高.随着G的增加,PENEG1-7.4%;G2-31%;G3-35.7%;LVI:G1-25.9%;G2-50%;G3-57.1%;PNI:G1-29.6%;G2-47.6%;G3-92.9%;NRG1-14.8%;G2-32.1%;G3-21.4%。分级不影响生长类型,也不直接影响NR的发生。pT和DOI增加了NM的频率,但我们没有观察到pT和DOI对LR的任何影响,PNI,还有LVI.研究组中的NY没有增加NR的风险。
■FOM内的肿瘤原发部位,TC,和pT分类是增加NM和LR风险的因素。然而,除了诱发NM发生的主要部位外,肿瘤的组织学结构是影响患者预后的最重要特征。PENE+的病例数,LVI+,PNI+,NM+,NR+随着G的增加而增加。尽管pT,DOI增加了NM的频率,我们没有观察到pT和DOI对LR的影响,PNI和LVI。因此,即使在FOM和TC至少G2的小肿瘤的情况下,也应每次进行选择性颈清扫。
The aim of the
study was to find clinical and pathological factors with the greatest prognostic significance in patients with OSCC. The analysis included 125 patients grouped according to the tumor primary site (TPS): the floor of the mouth (FOM), tongue (TC) and retromolar triangle (RMT). Grading (G), tumor size (pT), nodal metastases (NM), local recurrence (LR), nodal recurrence (NR), perineural invasion (PNI), lymphovascular invasion (LVI), extranodal extension (pENE), and nodal yield (NY) were evaluated in each group.
UNASSIGNED: With regard to TPS, FOM appeared to be the most metastatic. However, the recurrence rate was similar to TC tumors, which were characterized by higher G than those in other locations. When analyzing G, the highest percentage of LR (40.5%) and NM (34.5%) was observed among patients with G2. As G increased, so did the number of pENE G1 - 7.4%; G2 - 31%; G3 - 35.7%; LVI: G1 - 25.9%; G2 - 50%; G3 - 57.1%; PNI: G1 - 29.6%; G2 - 47.6%; G3 - 92.9%; NR G1 - 14.8%; G2 - 32.1%; G3 - 21.4%. Grading did not affect the type of growth and did not directly affect the occurrence of NR. pT and DOI increased the frequency of NM but we did not observe any effect of pT and DOI on LR, PNI, and LVI. NY in the
study group did not increase the risk of NR.
UNASSIGNED: Tumor primary sites within the FOM, TC, and pT classification are the factors that increase the risk of NM and LR. However, apart from the primary site predisposing to the occurrence of NM, the histological structure of the tumor turned out to be the most important feature affecting the patient\'s prognosis. The number of cases of pENE+, LVI+, PNI+, NM+, and NR+ increased with the increase in G. Although the pT, DOI increased the frequency of NM, we did not observe the effect of the pT and DOI on LR, PNI and LVI. Thus, even in the case of a small tumor of the FOM and TC with at least G2, elective neck dissection should be performed each time.