背景:人类非洲锥虫病(HAT),也被称为昏睡病,恰加斯病是由布鲁氏锥虫和克鲁氏锥虫引起的被忽视的热带病,分别。由于这些疾病的毒性,这些疾病在治疗中提出了重大挑战,低功效,以及与当前疗法相关的耐药菌株。
背景:半胱氨酸蛋白酶在这些寄生虫的生命周期中起着至关重要的作用,使它们成为治疗干预的潜在目标。来自植物的天然抑制剂,海洋生物,和微生物显示出开发新疗法的希望。
方法:本综述调查了天然抑制剂作为HAT和恰加斯病治疗药物的潜力。它从各种研究中汇编PubMed和PubChem信息,以概述其活动和特征,包括它们抑制半胱氨酸蛋白酶的能力,调节宿主的免疫反应,并干扰其他寄生虫蛋白。
结果:几种天然抑制剂,比如小檗碱,姜黄素,还有单宁,已被识别和表征。这些抑制剂在体外和体内实验中都显示出令人鼓舞的结果,表明它们作为HAT和恰加斯病治疗剂的潜力。
结论:半胱氨酸蛋白酶的天然抑制剂为开发针对HAT和恰加斯病的新疗法提供了有希望的途径。需要进一步的研究来确定其他天然抑制剂,并优化其对人类使用的功效和安全性。这项研究的意义在于它可能有助于发现有效的,安全,和负担得起的治疗这些被忽视的热带病。
BACKGROUND: Human African Trypanosomiasis (HAT), also known as sleeping sickness, and Chagas disease are neglected tropical diseases caused by Trypanosoma brucei and Trypanosoma cruzi, respectively. These diseases present significant challenges in treatment due to the toxicity, low efficacy, and drug-resistant strains associated with current therapies.
BACKGROUND: Cysteine proteases play vital roles in the life cycles of these parasites, making them potential targets for therapeutic intervention. Natural inhibitors sourced from plants, marine organisms, and microorganisms show promise for developing novel therapies.
METHODS: This review surveys the potential of natural inhibitors as therapeutic agents against HAT and Chagas disease. It compiles PubMed and PubChem information from various studies to provide an overview of their activities and characteristics, including their ability to inhibit cysteine proteases, modulate the host immune response, and interfere with other parasite proteins.
RESULTS: Several natural inhibitors, such as berberine, curcumin, and tannins, have been identified and characterized. These inhibitors have demonstrated encouraging outcomes in both in vitro and in vivo experiments, indicating their potential as therapeutic agents for HAT and Chagas disease.
CONCLUSIONS: Natural inhibitors of cysteine proteases offer a promising avenue for developing novel therapies against HAT and Chagas disease. Further research is needed to identify additional natural inhibitors and optimize their efficacy and safety for human use. The significance of this study lies in its potential to contribute to the discovery of effective, safe, and affordable treatments for these neglected tropical diseases.