环糊精,通常用作抗真菌制剂中的赋形剂,以改善宿主分子的理化性质和可用性,如果没有复杂的活性物质,还没有系统地研究它们的作用和生物活性。本文评估了各种环糊精对测试生物念珠菌的生理影响。这项研究检查了它们对酵母生长的影响,生存能力,生物膜形成和形态变化。本机ACD,BCD,在静态和动态系统中,在0.5-12.5mM浓度范围内研究了随机甲基化的α-和β-CD以及季铵α-CD和β-CD。研究表明,某些环糊精在动态系统中表现出显著的抗真菌作用(高达69%);然而,静态系统中生物膜的形成增强。这些影响的大小受到几个变量的影响,包括内腔的大小,环糊精的浓度和结构,接触时间。此外,研究发现,CD在静态和动态系统中都表现出不同的效果,可能与它们形成聚集体的趋势有关。研究结果表明,环糊精可能具有作为抗真菌剂或生长促进剂的潜力,取决于它们的结构和周围环境。
Cyclodextrins, commonly used as excipients in antifungal formulations to improve the physicochemical properties and availability of the host molecules, have not been systematically studied for their effects and bioactivity without a complex active substance. This paper evaluates the effects of various
cyclodextrins on the physiology of the test organism Candida boidinii. The research examines their impact on yeast growth, viability, biofilm formation and morphological changes. Native ACD, BCD, randomly methylated α- and β-CD and quaternary ammonium α-CD and β-CD were investigated in the 0.5-12.5 mM concentration range in both static and dynamic systems. The study revealed that certain
cyclodextrins exhibited notable antifungal effects (up to ~69%) in dynamic systems; however, the biofilm formation was enhanced in static systems. The magnitude of these effects was influenced by several variables, including the size of the internal cavity, the concentration and structure of the
cyclodextrins, and the contact time. Furthermore, the study found that CDs exhibited distinct effects in both static and dynamic systems, potentially related to their tendency to form aggregates. The findings suggest that
cyclodextrins may have the potential to act as antifungal agents or growth promoters, depending on their structure and surrounding environments.