目的:许多研究已经检查了姜黄素/姜黄对血压的影响以及据称导致高血压的因素。在这篇系统综述和荟萃分析中,我们试图总结现有的关于研究这一假设的随机对照试验(RCTs)的文献.
方法:在线数据库(PubMed,Scopus,WebofScience核心合集,科克伦图书馆,和谷歌学者)从成立之初到2022年10月都进行了搜索。我们使用Cochrane质量评估工具来评估偏倚风险。感兴趣的结果包括收缩压(SBP),舒张压(DBP),血管细胞粘附分子-1(VCAM-1)和细胞内粘附分子-1(ICAM-1)的血液水平,血流介导的血管舒张(FMD),和脉搏波速度(PWV)。得出并报告了加权平均差(WMD)。在研究之间存在显著异质性的情况下,进行了亚组分析.显著性水平被认为是P值<0.05。
结果:最后,纳入4182项研究中的35项RCT。我们的研究结果表明,姜黄素/姜黄补充剂显着改善SBP(WMD:-2.02mmHg;95%CI:-2.85,-1.18),DBP(WMD:-0.82mmHg;95%CI:-1.46,-0.18),VCAM-1(WMD:-39.19ng/mL;95%CI:-66.15,-12.23),和口蹄疫(大规模杀伤性武器:2.00%;95%CI:1.07,2.94)。然而,它没有显着改变ICAM-1的水平(WMD:-17.05ng/ml;95%CI:-80.79,46.70),或PWV(WMD:-79.53cm/s;95%CI:-210.38,51.33)。
结论:补充姜黄素/姜黄似乎可以作为改善血压和内皮功能的补充方法。然而,需要进一步的研究来阐明其对循环中炎症黏附分子的影响.
A number of studies have examined the impact of curcumin/turmeric on blood pressure and the factors allegedly responsible for hypertension. In this systematic
review and meta-analysis, we tried to sum up the existing literature on randomized controlled trials (RCTs) investigating this hypothesis.
Online databases (PubMed, Scopus, Web of Science Core Collection, Cochrane Library, and Google Scholar) were searched from inception up to October 2022. We used the cochrane quality assessment tool to evaluate the risk of bias. Outcomes of interest included systolic blood pressure (SBP), diastolic blood pressure (DBP), blood levels of vascular cell adhesion molecule-1 (VCAM-1) and intracellular adhesion molecule-1 (ICAM-1), flow-mediated vasodilation (FMD), and pulse-wave velocity (PWV). Weighted mean differences (WMDs) were derived and reported. In case of significant between-study heterogeneity, subgroup analyses were carried out. Significance level was considered as P-values<0.05.
Finally, 35 RCTs out of 4182 studies were included. Our findings suggested that curcumin/turmeric supplementation significantly improved SBP (WMD: -2.02 mmHg; 95 % CI: -2.85, -1.18), DBP (WMD: -0.82 mmHg; 95 % CI: -1.46, -0.18), VCAM-1 (WMD: -39.19 ng/mL; 95 % CI: -66.15, -12.23), and FMD (WMD: 2.00 %; 95 % CI: 1.07, 2.94). However, it did not significantly change levels of ICAM-1 (WMD: -17.05 ng/ml; 95 % CI: -80.79, 46.70), or PWV (WMD: -79.53 cm/s; 95 % CI: -210.38, 51.33).
It seems that curcumin/turmeric supplementation could be regarded as a complementary method to improve blood pressure and endothelial function. However, further research is needed to clarify its impact on inflammatory adhesion molecules in the circulation.