Consistency

一致性
  • 文章类型: Journal Article
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  • 文章类型: Journal Article
    随着大脑结构和功能在整个童年和青春期经历复杂的变化,年龄是神经影像学研究的关键考虑因素,特别是那些有神经发育状况的人。然而,尽管越来越多地使用大型,基于联盟的数据集,用于检查神经典型和神经分化人群的大脑结构和功能,目前尚不清楚与年龄相关的变化在数据集之间是否一致,以及与样本特征差异相关的不一致,如人口统计学和表型特征,存在。为了解决这个问题,我们在两个神经多样性数据集中建立了脑结构(区域皮质厚度和区域表面积;N=1218)和功能(静息状态功能连接强度;N=1254)的年龄相关变化模型:安大略省神经发育网络和健康脑网络。我们检查了这些模型的偏差在数据集之间是否不同,并探讨这些偏差是否与人口统计学和临床变量相关.我们发现两个数据集之间在测量整个大脑的皮质表面积和功能连接强度方面存在显着差异。对于皮质表面积的区域测量,差异的模式与种族/民族有关,而对于功能连接强度,观察到与头部运动呈正相关.我们的发现强调,大脑中与年龄相关的变化模式可能受到人口统计学和表型特征的影响。因此,未来的研究在分析中检查或控制年龄影响时应该考虑这些因素。
    With brain structure and function undergoing complex changes throughout childhood and adolescence, age is a critical consideration in neuroimaging studies, particularly for those of individuals with neurodevelopmental conditions. However, despite the increasing use of large, consortium-based datasets to examine brain structure and function in neurotypical and neurodivergent populations, it is unclear whether age-related changes are consistent between datasets and whether inconsistencies related to differences in sample characteristics, such as demographics and phenotypic features, exist. To address this, we built models of age-related changes of brain structure (regional cortical thickness and regional surface area; N = 1218) and function (resting-state functional connectivity strength; N = 1254) in two neurodiverse datasets: the Province of Ontario Neurodevelopmental Network and the Healthy Brain Network. We examined whether deviations from these models differed between the datasets, and explored whether these deviations were associated with demographic and clinical variables. We found significant differences between the two datasets for measures of cortical surface area and functional connectivity strength throughout the brain. For regional measures of cortical surface area, the patterns of differences were associated with race/ethnicity, while for functional connectivity strength, positive associations were observed with head motion. Our findings highlight that patterns of age-related changes in the brain may be influenced by demographic and phenotypic characteristics, and thus future studies should consider these when examining or controlling for age effects in analyses.
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  • 文章类型: Journal Article
    慢性正己烷中毒在中国小型和微型印刷行业的工人中普遍存在。尽管如此,这些部门对职业健康风险评估的研究有限。在关键岗位进行全面的风险评估,提出有效的应对措施至关重要。
    数据来自32家小型和微型印刷企业的84个关键职位。根据中国标准测试空气样品的正己烷暴露水平。采用了五种风险评估模型:COSHH,EPA,妈妈,ICMM,和中国技术指南GBZ/T289-2017。分析了这些模型结果的一致性。
    84个工作岗位的工人被分为四个暴露组,每天暴露于正己烷8-10小时,每周5-6天。大多数职位的自动化水平较低(印刷行业为96.9%,5.9%的油调合,粘贴率为42.9%),而其他人是手动的。局部通风率在油混合中明显较低(23.5%),清洁(14.3%),和粘贴组(9.5%)。正己烷浓度超过中国职业限值15.6%的印刷业,17.7%的油调合,和21.4%的清洁组。风险评估模型将超过60%的工作组确定为高风险。七种风险评估方法之间存在显着差异(p<0.05)。一致性分析显示,中国综合指数和暴露指数方法之间的一致性中等(k=0.571,p<0.01)。
    技术指南GBZ/T289-2017中的中国合成和暴露指数方法对于评估小型和微型印刷企业的正己烷暴露风险是实用和可靠的。发现清洁和印刷角色正己烷暴露的风险最高。这些发现为有针对性的风险管理策略提供了宝贵的见解,以保护行业中的工人健康。
    UNASSIGNED: Chronic n-Hexane poisoning is prevalent among workers in small and micro printing industries in China. Despite this, there is limited research on occupational health risk assessment in these sectors. Conducting comprehensive risk assessments at key positions and proposing effective countermeasures are essential.
    UNASSIGNED: Data were collected from 84 key positions across 32 small and micro-sized printing enterprises. Air samples were tested for n-Hexane exposure levels in accordance with Chinese standards. Five risk assessment models were employed: COSHH, EPA, MOM, ICMM, and Technical Guide GBZ/T 289-2017 of China. The consistency of results across these models was analyzed.
    UNASSIGNED: Workers in 84 job positions were categorized into four exposure groups, with exposure to n-Hexane for 8-10 h daily, 5-6 days weekly. Most positions operated with low automation levels (96.9% in printing, 5.9% in oil blending, and 42.9% in pasting), while others were manual. Localized ventilation rates were notably low in oil blending (23.5%), cleaning (14.3%), and pasting (9.5%) groups. n-Hexane concentrations exceeded Chinese occupational limits in 15.6% of printing, 17.7% of oil blending, and 21.4% of cleaning groups. Risk assessment models identified over 60% of work groups as high risk. Significant differences (p < 0.05) were found among the seven risk assessment methods. Consistency analysis revealed moderate agreement between the Chinese synthesis index and exposure index methods (k = 0.571, p < 0.01).
    UNASSIGNED: The Chinese synthesis and exposure index methods from Technical Guide GBZ/T 289-2017 are practical and reliable for assessing n-Hexane exposure risks in small and micro printing enterprises. Cleaning and printing roles were found to be at the highest risk for n-Hexane exposure. These findings provide valuable insights for targeted risk management strategies to protect workers\' health in the industry.
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  • 文章类型: Journal Article
    据报道,个性化的皮质功能网络分组在3.0T时具有很高的可重复性。鉴于皮质网络的复杂性和超高场5.0TMRI提供的灵敏度大大提高,不同磁场之间的分割一致性尚不清楚。
    基于空间和功能连通性分析,探讨在3.0T和5.0TMRI下个性化皮质功能网络分割的一致性和稳定性。
    招募了30名健康的年轻参与者。每个受试者在不到48小时内以随机顺序在3.0T和5.0T进行静息状态fMRI。使用先前提出的迭代算法对每个受试者进行个性化的皮质功能网络进行分组。Dice系数用于评估3.0T至5.0T之间的分块网络的空间一致性。使用欧几里得距离和图论度量来评估功能连通性(FC)一致性。
    由18个网络组成的功能性皮质图谱在3.0T和5.0T分别被分割。对于同一受试者,这些网络在3.0T和5.0T的空间一致性显着高于个体间。对于同一受试者,在3.0T和5.0T下获得的18个网络之间的FC高度一致。在3.0T和5.0T之间发现了图论指标中的正交叉相关。
    在3.0T和5.0T时的个性化皮质功能网络在空间和功能上都显示出一致且稳定的分割结果。5.0TMR提供了比3.0T更好的功能子网络特性。
    UNASSIGNED: Individualized cortical functional networks parcellation has been reported as highly reproducible at 3.0 T. However, in view of the complexity of cortical networks and the greatly increased sensitivity provided by ultra-high field 5.0 T MRI, the parcellation consistency between different magnetic fields is unclear.
    UNASSIGNED: To explore the consistency and stability of individualized cortical functional networks parcellation at 3.0 T and 5.0 T MRI based on spatial and functional connectivity analysis.
    UNASSIGNED: Thirty healthy young participants were enrolled. Each subject underwent resting-state fMRI at both 3.0 T and 5.0 T in a random order in less than 48 h. The individualized cortical functional networks was parcellated for each subject using a previously proposed iteration algorithm. Dice coefficient was used to evaluate the spatial consistency of parcellated networks between 3.0 T and 5.0 T. Functional connectivity (FC) consistency was evaluated using the Euclidian distance and Graph-theory metrics.
    UNASSIGNED: A functional cortical atlas consisting of 18 networks was individually parcellated at 3.0 T and 5.0 T. The spatial consistency of these networks at 3.0 T and 5.0 T for the same subject was significantly higher than that of inter-individuals. The FC between the 18 networks acquired at 3.0 T and 5.0 T were highly consistent for the same subject. Positive cross-subject correlations in Graph-theory metrics were found between 3.0 T and 5.0 T.
    UNASSIGNED: Individualized cortical functional networks at 3.0 T and 5.0 T showed consistent and stable parcellation results both spatially and functionally. The 5.0 T MR provides finer functional sub-network characteristics than that of 3.0 T.
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  • 文章类型: Journal Article
    成年人在语音处理的一致性方面有文献记载的个体差异,在神经和行为层面。一些成年人对语音的神经反应比其他人更一致,由称为频率跟随反应(FFR)的事件相关电位测量;类似地,一些成年人对母语语音的行为反应比其他人更一致,通过两种替代强制选择(2AFC)和视觉模拟缩放(VAS)任务来衡量。成年人在感知非母语语音的成功程度上也有所不同。有趣的是,目前尚不清楚这些差异是否与个体有关.在目前的研究中,以英语为母语的成年人完成了母语语音感知任务(2AFC和VAS),非母语(德语)语音感知任务,和FFR记录会话。从这些任务中,我们得出了参与者对本地语音的神经和行为反应以及他们的非本地感知能力的一致性度量。然后,我们检查了这些措施中个体差异之间的关系。对行为测量的分析表明,对本地声音的反应更加一致,可以预测对陌生的德国声音的感知更加成功。神经和行为数据分析未显示FFR一致性与我们的语音感知测量之间的明确关系。这项多模式工作进一步加深了我们对成年人语音处理中个体差异的理解,并可能最终导致个性化的方法来增强成年后非母语的习得。
    There are documented individual differences among adults in the consistency of speech sound processing, both at neural and behavioural levels. Some adults show more consistent neural responses to speech sounds than others, as measured by an event-related potential called the frequency-following response (FFR); similarly, some adults show more consistent behavioural responses to native speech sounds than others, as measured by two-alternative forced choice (2AFC) and visual analog scaling (VAS) tasks. Adults also differ in how successfully they can perceive non-native speech sounds. Interestingly, it remains unclear whether these differences are related within individuals. In the current study, native English-speaking adults completed native phonetic perception tasks (2AFC and VAS), a non-native (German) phonetic perception task, and an FFR recording session. From these tasks, we derived measures of the consistency of participants\' neural and behavioural responses to native speech as well as their non-native perception ability. We then examined the relationships among individual differences in these measures. Analysis of the behavioural measures revealed that more consistent responses to native sounds predicted more successful perception of unfamiliar German sounds. Analysis of neural and behavioural data did not reveal clear relationships between FFR consistency and our phonetic perception measures. This multimodal work furthers our understanding of individual differences in speech processing among adults, and may eventually lead to individualized approaches for enhancing non-native language acquisition in adulthood.
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  • 文章类型: Journal Article
    目的:由于其在确保学生评估一致性方面的可靠性和有效性,在评估和评分学生表现方面的使用在教师中变得更加突出。然而,有有限的证据表明,在分析性标记规则和整体标记规则之间,审查员的判断是一致的。
    方法:因此,我们旨在通过分析两种规则类型之间的平均标记差异和裁定数量以及两名评估者之间的评估者间可靠性,比较澳大利亚大学使用整体标记方法和分析规则给出的标记的一致性.我们分析了2016年至2021年荣誉医学生项目手稿的所有分数。我们比较了使用Kruskal-Wallis检验和Welcht检验分级的平均标记差异。我们使用卡方检验来比较每种标题类型的裁定频率。我们通过使用Pearson相关性比较两个审查员之间的分数来评估评估者间的可靠性。
    结果:我们发现分析规则具有较低的平均标记差异,需要较少的裁决者。与整体标记相比,我们显示出给定标记的一致性与分析规则的使用之间存在很强的正相关。皮尔逊相关性显示,当使用分析量规时,两名评估员获得的分数之间的相关性较低但较强(r=0.36),与整体标记规则相比(r=0.24)。
    结论:我们的研究结果表明,分析规则的使用可能会增加两个独立的考官在对医学生的工作进行评分时的一致性和可靠性。
    OBJECTIVE: The use of analytic rubrics in assessing and grading students\' performance has become more prominent among instructors due to its reliability and validity in ensuring consistency in student evaluation. However, there is limited evidence demonstrating the consistency of examiner judgments between analytic marking rubrics and holistic marking rubrics.
    METHODS: Therefore, we aimed to compare the consistency of marks given using holistic marking methods and analytic rubrics at an Australian university by analyzing the mean mark differences and number of adjudications between two rubric types as well as the inter-rater reliability between two assessors. We analyzed all scores for project manuscripts between 2016 and 2021 for Honours medical students. We compared the mean mark differences graded using the Kruskal-Wallis test and Welch t-test. We used chi-squared tests to compare the frequency of adjudications for each rubric type. We assessed interrater reliability by comparing the marks between the two examiners utilizing Pearson correlation.
    RESULTS: We found that analytic rubrics have lower mean mark differences and fewer adjudicators are required. We showed a strong positive association between the consistency of marks given and the use of analytic rubrics when compared to holistic marking. Pearson correlation showed a low but stronger correlation between marks awarded by the two assessors when analytic rubrics were used (r = 0.36), compared to holistic marking rubrics (r = 0.24).
    CONCLUSIONS: Our findings suggest that the use of analytic rubrics may increase the consistency and reliability between two independent examiners in marking medical students\' work.
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  • 文章类型: Journal Article
    本文报告了两个闪存模式实验,这些实验测试了小(2-4)基数的冗余描述,边界线(5-8)基数,和颜色在参考交流中。它为小基数更突出的想法提供了进一步的支持(由于subitizing),对视觉环境不太敏感,因此产生比颜色更高的超规格率。因为更大的显著性,与颜色形容词相比,俄语使用者更经常使用数字的前名词位置。本文还研究了边界基数,并论证了影响其显著性的顺序因素,因为订购的物品可以在小部分被感知。边界基数的有序表示模式导致比无序基数更高的超规范率和更高的标称位置百分比。本文为小的一致性提供了进一步的证据,边界基数,和颜色的人的选择,以最低限度地指定或过度指定在参照通信给定的对象。
    This paper reports on two flash-mode experiments that test redundant descriptions of small (2-4) cardinalities, borderline (5-8) cardinalities, and color in referential communication. It provides further support for the idea that small cardinalities are more salient (due to subitizing), less sensitive to visual context, and therefore give rise to higher over-specification rates than color. Because of greater salience, Russian speakers more often use prenominal positions for numerals than for color adjectives. The paper also investigates borderline cardinalities and argues for the order factor that affects their salience, since ordered items can be perceived in small subitized parts. The ordered mode of presentation of the borderline cardinalities leads to higher over-specification rates and to higher percentages of prenominal positions than the unordered one. The paper provides further evidence for the consistency of small, borderline cardinalities, and color in people\'s choices to minimally specify or over-specify given objects in referential communication.
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  • 文章类型: Journal Article
    背景:计算特定尺寸剂量估计值(SSDE)需要根据计算机断层扫描(CT)图像测量患者的前后(AP)和侧向厚度。然而,由于观察者之间和观察者之间的差异,这些测量可能会发生变化。本研究旨在研究这些变化对计算的SSDE准确性的影响。
    方法:邀请了4名具有1-10年经验的放射技师测量30个胸部的AP和外侧厚度,腹部,和骨盆CT图像。图像来自基于互联网的数据库,并匿名用于分析。使用MicroDicom软件训练观察者进行测量,并要求1周后重复测量。这项研究获得了Taibah大学机构审查委员会的批准,并从观察员处获得书面知情同意书.使用Python库Pingouin(版本0.5.3)进行统计分析,Seaborn(版本0.12.2),和Matplotlib(版本3.7.1)。
    结果:研究表明,对于计算的有效直径和AP厚度测量,观察者之间具有出色的一致性,组内相关系数(ICC)值分别为0.95和0.96。横向厚度测量的一致性较低,ICC值为0.89。第二轮测量产生了几乎相同水平的观察员之间的协议,有效直径的ICC值为0.97,1.0用于AP厚度,横向厚度为0.88。当观察者的一致性被检查时,计算的有效直径具有出色的一致性,所有观察者的ICC值范围为0.91至1.0。尽管横向厚度测量的一致性较低,但仍观察到了这一点。其ICC值范围为0.78至1.0。
    结论:研究结果表明,计算SSDE所需的测量结果对于观察者之间和观察者之间的差异是稳健的。这对于SSDE的临床使用为CT扫描设置诊断参考水平很重要。
    BACKGROUND: Calculating size-specific dose estimates (SSDEs) requires measurement of the patient\'s anteroposterior (AP) and lateral thickness based on computed tomography (CT) images. However, these measurements can be subject to variation due to inter-observer and intra-observer differences. This study aimed to investigate the impact of these variations on the accuracy of the calculated SSDE.
    METHODS: Four radiographers with 1-10 years of experience were invited to measure the AP and lateral thickness on 30 chest, abdomen, and pelvic CT images. The images were sourced from an internet-based database and anonymized for analysis. The observers were trained to perform the measurements using MicroDicom software and asked to repeat the measurements 1 week later. The study was approved by the institutional review board at Taibah University, and written informed consent was obtained from the observers. Statistical analyses were performed using Python libraries Pingouin (version 0.5.3), Seaborn (version 0.12.2), and Matplotlib (version 3.7.1).
    RESULTS: The study revealed excellent inter-observer agreement for the calculated effective diameter and AP thickness measurements, with Intraclass correlation coefficients (ICC) values of 0.95 and 0.96, respectively. The agreement for lateral thickness measurements was lower, with an ICC value of 0.89. The second round of measurements yielded nearly the same levels of inter-observer agreement, with ICC values of 0.97 for the effective diameter, 1.0 for AP thickness, and 0.88 for lateral thickness. When the consistency of the observer was examined, excellent consistency was found for the calculated effective diameter, with ICC values ranging from 0.91 to 1.0 for all observers. This was observed despite the lower consistency in the lateral thickness measurements, which had ICC values ranging from 0.78 to 1.0.
    CONCLUSIONS: The study\'s findings suggest that the measurements required for calculating SSDEs are robust to inter-observer and intra-observer differences. This is important for the clinical use of SSDEs to set diagnostic reference levels for CT scans.
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  • 文章类型: Journal Article
    Objective: To compare the consistency of lymphoma multigene detection panels based on next-generation sequencing (NGS) with FISH detection of B-cell lymphoma gene rearrangement. Methods: From January 2019 to May 2023, fusion genes detected by lymphoma-related 413 genes that targeted capture sequencing of 489 B-cell lymphoma tissues embedded in paraffin were collected from Henan Cancer Hospital, and the results were compared with simultaneous FISH detection of four break/fusion genes: BCL2, BCL6, MYC, and CCND1. Consistency was defined as both methods yielding positive or negative results for the same sample. The relationship between fusion mutation abundance in NGS and the positivity rate of cells in FISH was also analyzed. Results: Kappa consistency analysis revealed high consistency between NGS and FISH in detecting the four B-cell lymphoma-related gene rearrangement (P<0.001 for all) ; however, the detection rates of positive individuals differed for the four genes. Compared with FISH, NGS demonstrated a higher detection rate for BCL2 rearrangement, a lower detection rate for BCL6 and MYC rearrangement, and a similar detection rate for CCND1 rearrangement. No correlation was found between fusion mutation abundance in NGS and the positivity rate of cells in FISH. Conclusions: NGS and FISH detection of B-cell lymphoma gene rearrangement demonstrate overall good consistency. NGS is superior to FISH in detecting BCL2 rearrangement, inferior in detecting MYC rearrangement, and comparable in detecting CCND1 rearrangement.
    目的: 比较基于二代测序(NGS)的淋巴瘤多基因检测包(panel)与FISH检测B细胞淋巴瘤基因重排的一致性。 方法: 收集2019年1月到2023年5月河南省肿瘤医院对489份石蜡包埋的B细胞淋巴瘤组织进行淋巴瘤相关的413个基因靶向捕获测序后发现的融合基因,与同步采用FISH检测BCL2、BCL6、MYC和CCND1 4种断裂/融合基因的结果进行比较。两种方法对同一个样本的检测结果均为阳性或阴性为一致。同时分析NGS中融合突变丰度与FISH中阳性细胞比率的关系。 结果: Kappa一致性分析显示NGS和FISH在检测4种B细胞淋巴瘤相关基因重排上有较高的一致性(P值均<0.001),但在阳性个体检出率上4种基因有所不同,NGS对BCL2重排的检出率高于FISH,对BCL6和MYC重排的检出率低于FISH,对CCND1重排的检出率与FISH相同。NGS中融合突变丰度与FISH中阳性细胞比率无相关性。 结论: NGS与FISH检测B细胞淋巴瘤基因重排总体上具有较好一致性。在检测BCL2重排上,NGS优于FISH;在检测MYC重排上,NGS劣于FISH;在检测CCND1重排上二者相当。.
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  • 文章类型: Journal Article
    受访者驱动的抽样(RDS)被广泛用于对没有抽样框架的HIV感染风险较高的人群进行抽样。然而,很少有研究来评估现实环境中RDS估计的一致性。我们使用来自国家艾滋病毒行为监测的数据对RDS估计的一致性进行了评估研究-在纽瓦克注射药物的人调查,新泽西州从2005年到2018年。基于RDS-I的人口参数估计,RDS-II,Gile的党卫军,和HCG进行了纵向和横截面比较。估计并比较了人口同质化统计数据和差异招募统计数据。将收敛图用于RDS诊断。对种群规模估计和种子偏差进行了敏感性分析。通过比较四个RDS估计器估计的时间不敏感种群参数和种群同质性统计量,研究发现,RDS-II和Gile'sSS可以提供纵向和横断面上一致的估计,以及关于性别和性取向的人口同质性统计.时间敏感人口参数估计的横截面比较也支持RDS-II和Gile的SS的一致性。然而,RDS-I和HCG在这些比较中表现不佳。总之,RDS估计器可能无法解决所有不一致问题,但建议使用RDS-II和Gile的SS对RDS样本进行称重,因为它们具有足够的一致性。
    Respondent-driven sampling (RDS) is widely used to sample populations with higher risk of HIV infection for whom no sampling frames exist. However, few studies have been done to assess the consistency of RDS estimators in real world settings. We conducted an assessment study on the consistency of RDS estimators using data from the National HIV Behavioral Surveillance - People Who Inject Drugs surveys in Newark, New Jersey from 2005 to 2018. Population parameter estimates based on RDS-I, RDS-II, Gile\'s SS, and HCG were compared longitudinally and cross-sectionally. Population homophily statistics and differential recruitment statistics were estimated and compared. Convergence plots were used for RDS diagnosis. Sensitivity analyses were conducted on population size estimates and seeds biases. By comparing time-insensitive population parameters and population homophily statistics estimated by four RDS estimators, the study found that RDS-II and Gile\'s SS could provide longitudinally and cross-sectionally consistent estimates and population homophily statistics on gender and sexual orientation. Cross-sectional comparison of time-sensitive population parameter estimates also supported the consistency of RDS-II and Gile\'s SS. However, RDS-I and HCG did not perform well in those comparisons. In conclusion, RDS estimators may not address all inconsistencies, but RDS-II and Gile\'s SS are recommended to weight RDS samples given enough consistency was observed in them.
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