背景:生活在美国农村地区的青少年的常规疫苗接种覆盖率低于生活在城市地区的青少年。我们试图衡量新兵训练营翻译(BCT)的效果,基于社区的参与性干预,农村青少年疫苗接种覆盖率。
方法:一项整群随机对照试验于2018年9月至2021年11月进行,涉及16个科罗拉多州农村县。干预县社区成员参与BCT,以制定干预措施,以改善当地的青少年疫苗接种。使用科罗拉多免疫信息系统测量青少年疫苗接种覆盖率。
结果:对于11-12岁的孩子,HPV起始,HPV最新,MenACWY,与干预前相比,对照组和干预组的Tdap疫苗接种覆盖率较低.对于干预组的11-12岁儿童,与对照组相比,干预后与干预前相比,HPV疫苗启动几率(调整后比值比[aROR]=0.93,95%:0.85~1.02,p=0.10)或最新HPV疫苗接种几率(aROR:1.10,95%CI:0.98~1.23,p=0.11)均无显著差异.在11-12岁的孩子中,干预组接种MenACWY和Tdap的比例下降幅度明显大于对照组.在13-17岁的年轻人中,HPV起始显著增加,HPV最新,MenACWY,两组的Tdap疫苗接种覆盖率从干预前到干预后,组间无显著差异。
结论:从干预前后,11-12岁的疫苗接种覆盖率略有下降,而13-17岁的疫苗接种覆盖率增加。我们没有看到BCT干预的效果。我们关于BCT改善疫苗摄取的有效性的发现可能无法推广,因为该研究与COVID-19大流行相吻合。
背景:这项研究已在ClinicalTrials.gov注册,NCT03955757。
BACKGROUND: Routine vaccination coverage for adolescents living in the rural US is lower than adolescents living in urban areas. We sought to measure the effect of Boot Camp Translation (BCT), a community-based participatory intervention, on rural adolescent vaccination coverage.
METHODS: A cluster randomized controlled
trial was performed September 2018-November 2021 involving 16 rural
Colorado counties. Intervention county community members engaged in BCT to develop interventions to improve adolescent vaccination locally. Adolescent vaccination coverage was measured using the
Colorado Immunization Information System.
RESULTS: For 11-12-year-olds, HPV initiation, HPV up-to-date, MenACWY, and Tdap vaccination coverage was lower post- versus pre-intervention in the control and intervention groups. For 11-12-year-olds in the intervention group, there was no significant difference post- versus pre-intervention in the odds of HPV vaccine initiation (adjusted ratio of odds ratios [aROR] = 0.93, 95 %: 0.85-1.02, p = 0.10) or up-to-date HPV vaccination (aROR: 1.10, 95 % CI: 0.98-1.23, p = 0.11) compared with the control group. Among 11-12-year-olds, the decrease in the proportion vaccinated with MenACWY and Tdap in the intervention group was significantly greater than the control group. Among 13-17-year-olds, there were significant increases in HPV initiation, HPV up-to-date, MenACWY, and Tdap vaccination coverage from pre- to post-intervention for both groups, with no significant differences between groups.
CONCLUSIONS: 11-12-year-old vaccination coverage decreased slightly from pre- to post-intervention while 13-17-year-old vaccination coverage increased. We saw no effect from the BCT intervention. Our findings about the effectiveness of BCT for improving vaccine uptake may not be generalizable because the
study coincided with the COVID-19 pandemic.
BACKGROUND: This
study was registered with ClinicalTrials.gov, NCT03955757.