Colonic Diseases

结肠疾病
  • 文章类型: Case Reports
    本文介绍了一名32岁女性患者因Bochdalek疝气而在胸腔中急性结肠嵌顿的情况。还发现了无症状的右Bochdalek疝气,这是一个罕见的发现。患者接受了剖腹手术,重新定位了嵌顿的器官,并初次闭合了左侧缺损。由于慢性肠道问题的症状,最初嵌顿的结肠的狭窄部分在一年后被切除。目前,从第一次手术开始18个月,患者的临床状况仍然良好,对包括狭窄结肠切除的二次手术有积极的临床反应,右侧Bochdalek疝气仍然无症状.
    This paper presents the case of a 32-year-old female patient with acute colon incarceration in the thoracic cavity due to Bochdalek hernia. An asymptomatic right Bochdalek hernia was also discovered, which is a rare finding. The patient underwent laparotomy with reposition of the incarcerated organs and primary closure of the left-sided defect. The stenotic portion of the originally incarcerated colon was resected one year later due to the symptoms of chronic bowel problems. At present, 18 months from the first surgery, the patient\'s clinical condition remains good with a positive clinical response to the secondary surgery involving resection of the stenotic colon, and the right Bochdalek hernia remains asymptomatic.
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  • 文章类型: Journal Article
    背景:我们的目的是描述为处理结肠镜相关穿孔而进行的手术干预的临床结果,并将这些结果与在择期和急诊环境中进行的匹配结直肠手术的结果进行比较。
    方法:我们纳入了2014-2017年国家手术质量改进计划中接受手术干预的内镜下结肠穿孔患者,参与者使用数据结肠直肠靶向程序文件。这项研究的主要结果是短期手术发病率和死亡率。在选择性(第2组)或急诊(第3组)的基础上,患者(第1组)与接受相同手术干预以其他适应症的对照组患者的比例为1:2。进行了双变量分析,以比较三组之间的分类变量,多因素logistic回归用于评估手术指征与术后30天结局之间的相关性.
    结果:共纳入590例患者。患者的平均年龄为66.5±13.6,女性占主导地位(381,64.6%)。大多数患者进行了开腹结肠切除术(365,61.9%),其余患者进行了缝合(140,23.7%)和腹腔镜结肠切除术(85,14.4%)。总死亡率为4.1%,三种技术之间的死亡率无统计学差异(P=0.468)。163例患者发生复合发病率(27.6%)。腹腔镜结肠切除术(14.1%)明显低于开腹结肠切除术和缝合方法的30.2%和29.4%(P=0.014)。因医源性结肠穿孔而接受结肠切除术的患者死亡率较低,感染率和败血症,以及与紧急结肠切除术的患者相比的出血事件。前一组与接受其他适应症的择期结肠切除术的患者之间的结果具有可比性。
    结论:结肠镜检查相关穿孔的手术治疗是安全有效的,其结果与择期结肠切除术患者相似。
    BACKGROUND: Our aim was to describe the clinical outcomes of surgical interventions performed for the management of colonoscopy-related perforations and to compare these outcomes with those of matched colorectal surgeries performed in elective and emergency settings.
    METHODS: We included patients with endoscopic colonic perforation who underwent surgical intervention from the 2014-2017 National Surgery Quality Improvement Program participant use data colorectal targeted procedure file. The primary outcome in this study was short term surgical morbidity and mortality. Patients (group 1) were matched with 1:2 ratio to control patients undergoing same surgical interventions for other indications on an elective (group 2) or emergency basis (group 3). Bivariate analysis was conducted to compare categorical variables between the three groups, and multivariate logistic regression was used to evaluate the association between the surgical indication and 30-day postoperative outcomes.
    RESULTS: A total of 590 patients were included. The average age of the patients was 66.5±13.6 with female gender predominance (381, 64.6%) The majority of patients underwent open colectomy (365, 61.9%) while the rest had suturing (140, 23.7%) and laparoscopic colectomy (85, 14.4%). Overall mortality occurred in 4.1% and no statistically significant difference in mortality was found between the three techniques (P=0.468). Composite morbidity occurred in 163 patients (27.6%). It was significantly lower in laparoscopic colectomy (14.1%) compared to 30.2% and 29.4% in open colectomy and suturing approaches (P=0.014). Patients undergoing colectomy for iatrogenic colonic perforation had less mortality, infection rates and sepsis, as well as bleeding episodes compared to those who had colectomy on an emergent basis. Outcomes were comparable between the former group and patients undergoing elective colectomy for other indications.
    CONCLUSIONS: Surgical management of colonoscopy related perforations is safe and effective with outcomes that are similar to that of patients undergoing elective colectomy.
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  • 文章类型: Case Reports
    儿童摄入磁铁会导致严重的并发症,既尖锐又长期。本病例报告讨论了一例多次吸磁的治疗方法,导致空肠结肠瘘,节段性肠扭转,肝脂肪变性,和晚期发现的肾结石。此外,我们进行了文献综述,以探讨磁铁摄入引起的肠瘘的特征。一名六岁女童因间歇性腹痛入院儿科消化内科,呕吐,腹泻持续两年。最初的鉴别诊断包括乳糜泻,囊性纤维化,炎症性肠病,肺结核,然而病因仍然难以捉摸。根据磁共振成像发现怀疑空肠结肠瘘后,咨询了小儿外科团队。体格检查未发现急腹症,但显示轻度腹胀。随后的上消化道系列和对比剂灌肠造影证实了空肠结肠瘘和节段性扭转。这个家庭后来报告说,孩子两年前吞下了一块磁铁,并且在1~2周内自行排出磁铁后,医学随访已经停止.手术干预对于纠正肠扭转和修复大的空肠结肠瘘是必要的。为了确定相关研究,我们根据PRISMA(系统评价和荟萃分析的首选报告项目)指南,对磁铁摄入和胃肠瘘进行了详细的文献检索.我们确定了44篇文章,其中包括55例急性期症状未出现且未观察到急腹症的病例。在29个案例中,磁铁摄入时间未知。在摄入时间已知的26例病例中,直到瘘管检测的平均持续时间为22.8天(范围:1~90天).47例经开腹手术进行瘘修补术。
    Magnet ingestion in children can lead to serious complications, both acutely and chronically. This case report discusses the treatment approach for a case involving multiple magnet ingestions, which resulted in a jejuno-colonic fistula, segmental intestinal volvulus, hepa-tosteatosis, and renal calculus detected at a late stage. Additionally, we conducted a literature review to explore the characteristics of intestinal fistulas caused by magnet ingestion. A six-year-old girl was admitted to the Pediatric Gastroenterology Department pre-senting with intermittent abdominal pain, vomiting, and diarrhea persisting for two years. Initial differential diagnoses included celiac disease, cystic fibrosis, inflammatory bowel disease, and tuberculosis, yet the etiology remained elusive. The Pediatric Surgery team was consulted after a jejuno-colonic fistula was suspected based on magnetic resonance imaging findings. The physical examination revealed no signs of acute abdomen but showed mild abdominal distension. Subsequent upper gastrointestinal series and contrast enema graphy confirmed a jejuno-colonic fistula and segmental volvulus. The family later reported that the child had swallowed a magnet two years prior, and medical follow-up had stopped after the spontaneous expulsion of the magnets within one to two weeks. Surgical intervention was necessary to correct the volvulus and repair the large jejuno-colonic fistula. To identify relevant studies, we conducted a detailed literature search on magnet ingestion and gastrointestinal fistulas according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. We identified 44 articles encompassing 55 cases where symptoms did not manifest in the acute phase and acute abdomen was not observed. In 29 cases, the time of magnet ingestion was unknown. Among the 26 cases with a known ingestion time, the average duration until fistula detection was 22.8 days (range: 1-90 days). Fistula repairs were performed via laparotomy in 47 cases.
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  • 文章类型: Case Reports
    背景:已经在人类以及患有阻塞性胃肠道疾病的犬患者中报道了由于心肌缺血引起的室性扩大。这是第一例有结肠扭转的犬心室扩大的病例报告,该病例在液体复苏和恢复心肌灌注后得以解决。
    方法:一个11岁的孩子,雄性绝育混种犬有一天的呕吐史,重弹,和嗜睡。体格检查发现了不规则的心律和间歇性脉搏不足。室性心律失常以室性早搏复合体(VPCs)为代表,在具有单导联(II)视图的3导联心电图(ECG)上受到赞赏。腹部X光片证实结肠扭转。在麻醉诱导之前,心室扩大对芬太尼或利多卡因无反应。患者被麻醉并通过抑制的体积描记波振幅(体积描记变异性)确定血管内容量不足,多普勒声音的可听软化,和更明显的脉搏缺陷。液体复苏是通过静脉内晶体和胶体液体治疗的组合来实现的,其中包括7.2%的高渗盐水和6%的hetastarch。液体复苏后,患者的心律转变为正常的窦性心律。结肠扭转经手术矫正。患者从麻醉中恢复良好,最终在5天后出院。
    结论:本病例报告强调心肌缺血可导致室性心律失常,比如室性反应。这是第一例有记载的结肠扭转犬患者的心室扩大病例。评估患者容量状态和适当的液体复苏以及连续心电图(ECG)监测对于全身麻醉下患者的稳定至关重要。
    BACKGROUND: Ventricular bigeminy due to myocardial ischemia has been reported in humans as well as in canine patients with obstructive gastrointestinal diseases. This is the first case report of ventricular bigeminy in a dog with a colonic torsion that resolved after fluid resuscitation and restoration of myocardial perfusion.
    METHODS: An 11-year-old, male neutered mixed breed dog presented with a one day history of vomiting, tenesmus, and lethargy. Physical examination identified an irregular heart rhythm and intermittent pulse deficits. A ventricular arrhythmia represented by ventricular premature complexes (VPCs) organized in bigeminy, was appreciated on a 3-lead electrocardiogram (ECG) with a single lead (II) view. Abdominal radiographs confirmed a colonic torsion. Prior to anesthetic induction, ventricular bigeminy was non responsive to fentanyl or lidocaine. The patient was anesthetized and intravascular volume deficit was identified by dampened plethysmographic wave amplitude (plethysomographic variability), audible softening of the Doppler sound, and more pronounced pulse deficits. Fluid resuscitation was achieved with a combination of intravenous crystalloid and colloid fluid therapy comprising 7.2% hypertonic saline and 6% hetastarch. The patient\'s cardiac rhythm converted to normal sinus after fluid resuscitation. The colonic torsion was surgically corrected. The patient recovered well from anesthesia and was ultimately discharged from the hospital 5 days later.
    CONCLUSIONS: The present case report highlights that myocardial ischemia can lead to ventricular arrythmias, such as ventricular bigeminy. This is the first documented case of ventricular bigeminy in the canine patient with a colonic torsion. Assessment of patient volume status and appropriate fluid resuscitation along with continuous electrocardiogram (ECG) monitoring are vital to patient stability under general anesthesia.
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  • 文章类型: Journal Article
    背景:脾瘘(CsF)是一种极为罕见的并发症。它的诊断和管理仍然知之甚少,由于其罕见的发生率。我们的目的是系统地回顾病因,临床特征,诊断,管理,和预后,以帮助临床医生更好地了解这种不寻常的并发症,并在遇到时提供帮助。
    方法:对OvidMEDLINE中CsF诊断的研究进行系统评价,OvidEmbase,Scopus,WebofScience,和WileyCochrane图书馆从1946年到2022年6月。此外,纳入了我们机构4例病例的回顾性研究.评估病例的患者特征(年龄,性别,和合并症),CsF特征包括原因,出现时的症状,诊断方法,管理方法,病理结果,术中并发症,术后并发症,30天死亡率,并收集预后。
    结果:分析了30例CsFs患者,包括我们机构的4例病例和26例单病例报告。大多数患者是男性(70%),平均年龄为56岁。最常见的病因是结肠淋巴瘤(30%)和结直肠癌(17%)。计算机断层扫描(CT)通常用于诊断(90%)。大约87%的患者接受了手术干预,最常见的部分切除(81%)的影响结肠和脾切除术(77%)。19名患者最初接受了手术治疗,12例患者最初接受非手术治疗。然而,11名非手术患者由于未解决的症状最终需要手术。术后并发症发生率为17%。25例(83%)患者通过手术干预缓解了症状。只有一名患者(3%)有术后死亡。
    结论:我们对全球30例病例的回顾是文献中最大的。CsF主要是肿瘤过程的并发症。CsF可以通过脾切除术和受影响的结肠切除术来成功和安全地治疗。术后并发症发生率低。
    BACKGROUND: A colosplenic fistula (CsF) is an extremely rare complication. Its diagnosis and management remain poorly understood, owing to its infrequent incidence. Our objective was to systematically review the etiology, clinical features, diagnosis, management, and prognosis to help clinicians gain a better understanding of this unusual complication and provide aid if it is to be encountered.
    METHODS: A systematic review of studies reporting CsF diagnosis in Ovid MEDLINE, Ovid EMBASE, Scopus, Web of Science, and Wiley Cochrane Library from 1946 to June 2022. Additionally, a retrospective review of four cases at our institution were included. Cases were evaluated for patient characteristics (age, sex, and comorbidities), CsF characteristics including causes, symptoms at presentation, diagnosis approach, management approach, pathology findings, intraoperative complications, postoperative complications, 30-day mortality, and prognosis were collected.
    RESULTS: Thirty patients with CsFs were analyzed, including four cases at our institution and 26 single-case reports. Most of the patients were male (70%), with a median age of 56 years. The most common etiologies were colonic lymphoma (30%) and colorectal carcinoma (17%). Computed tomography (CT) was commonly used for diagnosis (90%). Approximately 87% of patients underwent a surgical intervention, most commonly segmental resection (81%) of the affected colon and splenectomy (77%). Nineteen patients were initially managed surgically, and 12 patients were initially managed nonoperatively. However, 11 of the nonoperative patients ultimately required surgery due to unresolved symptoms. The rate of postoperative complications was (17%). Symptoms resolved with surgical intervention in 25 (83%) patients. Only one patient (3%) had had postoperative mortality.
    CONCLUSIONS: Our review of 30 cases worldwide is the largest in literature. CsFs are predominantly complications of neoplastic processes. CsF may be successfully and safely treated with splenectomy and resection of the affected colon, with a low rate of postoperative complications.
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  • 文章类型: Case Reports
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  • 文章类型: Journal Article
    背景:结直肠癌(CRC)与营养素之间的关系已被频繁研究。然而,饮食中的营养密度与CRC风险的相关性研究较少。这项研究旨在调查伊朗成年人中CRC与自然营养丰富(NNR)评分之间的关系。
    方法:这项病例对照研究纳入了德黑兰地区160名35-70岁的结直肠癌患者和320名对照,伊朗。使用168项食物频率问卷评估饮食摄入量。通过计算包括蛋白质在内的14种营养素的平均每日值,获得NNR评分。维生素A,C,D,E,B1,B2,B12,钙,锌,铁,叶酸,钾和不饱和脂肪酸。
    结果:关于NNR评分各组分的膳食摄入量,病例组多不饱和脂肪摄入量较低(15.41±4.44vs16.54±4.20g/天,p=0.01),维生素E(10.15±4.16vs13.1±5.33;p=0.001),维生素B1(2±0.86vs2.19±0.84毫克/天,p=0.03)和叶酸(516.45±96.59vs571.05±80.31;p=0.001)和更高的油酸摄入量(8.21±5.46vs5.59±3.17g/天,p=0.01)与对照组相比。调整混杂因素后,结直肠癌风险与NNR评分呈负相关(OR0.92;95%CI0.88至0.97;p=0.03)。
    结论:低NNR评分可能与CRC相关。如果被未来的纵向研究证实,这一结果可能有助于通过推荐营养丰富的饮食来预防CRC.
    The association between colorectal cancer (CRC) and nutrients has been studied frequently. However, the association of nutrient density of diets with the risk of CRC has been less studied. This study aimed to investigate the association between CRC and naturally nutrient rich (NNR) score in Iranian adults.
    This case-control study included 160 patients with colorectal cancer and 320 controls aged 35-70 years in Tehran, Iran. Dietary intake was assessed using a 168-item food frequency questionnaire. The NNR score was obtained by calculating the average daily value of 14 nutrients including protein, vitamins A, C, D, E, B1, B2, B12, calcium, zinc, iron, folate, potassium and unsaturated fatty acids.
    Regarding dietary intake of the components of NNR score, the case group had a lower intake of polyunsaturated fat (15.41±4.44 vs 16.54±4.20 g/day, p=0.01), vitamin E (10.15±4.16 vs 13.1±5.33; p=0.001), vitamin B1 (2±0.86 vs 2.19±0.84 mg/day, p=0.03) and folate (516.45±96.59 vs 571.05±80.31; p=0.001) and a higher intake of oleic acid (8.21±5.46 vs 5.59±3.17 g/day, p=0.01) compared with the control group. Colorectal cancer risk was inversely associated with the NNR score after adjusting for the confounders (OR 0.92; 95% CI 0.88 to 0.97; p=0.03).
    Low NNR scores may be linked to CRC. If confirmed by future longitudinal research, this result may help prevent CRC by recommending nutrient-rich diets.
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  • 文章类型: Case Reports
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  • 文章类型: Case Reports
    背景:自发性结肠穿孔可分为无菌和特发性。Stercoral型与慢性便秘有关,因此,它在婴儿和儿童中很少见。特发性类型是偶发性的,可能发生在任何年龄。诊断或治疗特发性结肠穿孔的延迟与高死亡率和发病率相关。关于直肠穿孔与其他病因或新生儿期相关的研究很少,它们对疾病发作和预后的影响尚不清楚。
    方法:我们报告一例2岁5个月大的奥罗莫男孩发烧,腹泻,呕吐,和5天持续时间的进行性腹痛。该男孩因怀疑腹膜炎而接受了剖腹探查术,直肠上三分之一的前部有一个约2.0厘米的穿孔。首先修复穿孔的直肠,并进行乙状结肠分流术。
    结论:了解儿童特发性结肠穿孔非常重要,一种罕见但危险的疾病,在延迟诊断或治疗的情况下具有高死亡率和发病率。对于存在腹胀和腹泻史超过5天的儿童,儿科医生和外科医生应将结肠穿孔视为病因。
    BACKGROUND: Spontaneous colon perforation can be classified into stercoral and idiopathic. Stercoral type is associated with chronic constipation, thus it is rare in infants and children. The idiopathic type is sporadic and could occur at any age. Delay in diagnosing or treating idiopathic colon perforation is associated with high mortality and morbidity rates. There are few studies on rectal perforation related to other etiologies or past the neonatal period, and their effect on disease onset and prognosis are unknown.
    METHODS: We report on a case of 2-year-and-5-month-old Oromo boy who presented with fever, diarrhea, vomiting, and progressive abdominal pain of 5-day duration. The boy underwent an exploratory laparotomy for suspected peritonitis and there was a single perforation of approximately 2.0 cm size in the anterior part of the upper one-third of rectum. The perforated rectum was repaired primarily and sigmoid divided diversion colostomy was carried out.
    CONCLUSIONS: It is important to be aware of idiopathic colon perforation in children, a rare but dangerous condition with high mortality and morbidity in cases of delayed diagnosis or management. Pediatricians and surgeons should consider colon perforation as a cause in children who present with abdominal distention and a history of diarrhea for more than 5 days.
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