PDF(Pubmed)
Abstract：
The association between colorectal cancer (CRC) and nutrients has been studied frequently. However, the association of nutrient density of diets with the risk of CRC has been less studied. This study aimed to investigate the association between CRC and naturally nutrient rich (NNR) score in Iranian adults.
This case-control study included 160 patients with colorectal cancer and 320 controls aged 35-70 years in Tehran, Iran. Dietary intake was assessed using a 168-item food frequency questionnaire. The NNR score was obtained by calculating the average daily value of 14 nutrients including protein, vitamins A, C, D, E, B1, B2, B12, calcium, zinc, iron, folate, potassium and unsaturated fatty acids.
Regarding dietary intake of the components of NNR score, the case group had a lower intake of polyunsaturated fat (15.41±4.44 vs 16.54±4.20 g/day, p=0.01), vitamin E (10.15±4.16 vs 13.1±5.33; p=0.001), vitamin B1 (2±0.86 vs 2.19±0.84 mg/day, p=0.03) and folate (516.45±96.59 vs 571.05±80.31; p=0.001) and a higher intake of oleic acid (8.21±5.46 vs 5.59±3.17 g/day, p=0.01) compared with the control group. Colorectal cancer risk was inversely associated with the NNR score after adjusting for the confounders (OR 0.92; 95% CI 0.88 to 0.97; p=0.03).
Low NNR scores may be linked to CRC. If confirmed by future longitudinal research, this result may help prevent CRC by recommending nutrient-rich diets.
This case-control study included 160 patients with colorectal cancer and 320 controls aged 35-70 years in Tehran, Iran. Dietary intake was assessed using a 168-item food frequency questionnaire. The NNR score was obtained by calculating the average daily value of 14 nutrients including protein, vitamins A, C, D, E, B1, B2, B12, calcium, zinc, iron, folate, potassium and unsaturated fatty acids.
Regarding dietary intake of the components of NNR score, the case group had a lower intake of polyunsaturated fat (15.41±4.44 vs 16.54±4.20 g/day, p=0.01), vitamin E (10.15±4.16 vs 13.1±5.33; p=0.001), vitamin B1 (2±0.86 vs 2.19±0.84 mg/day, p=0.03) and folate (516.45±96.59 vs 571.05±80.31; p=0.001) and a higher intake of oleic acid (8.21±5.46 vs 5.59±3.17 g/day, p=0.01) compared with the control group. Colorectal cancer risk was inversely associated with the NNR score after adjusting for the confounders (OR 0.92; 95% CI 0.88 to 0.97; p=0.03).
Low NNR scores may be linked to CRC. If confirmed by future longitudinal research, this result may help prevent CRC by recommending nutrient-rich diets.
摘要：
背景：结直肠癌（CRC）与营养素之间的关系已被频繁研究。然而,饮食中的营养密度与CRC风险的相关性研究较少。这项研究旨在调查伊朗成年人中CRC与自然营养丰富（NNR）评分之间的关系。
方法：这项病例对照研究纳入了德黑兰地区160名35-70岁的结直肠癌患者和320名对照，伊朗。使用168项食物频率问卷评估饮食摄入量。通过计算包括蛋白质在内的14种营养素的平均每日值，获得NNR评分。维生素A,C,D,E,B1，B2，B12，钙，锌，铁,叶酸,钾和不饱和脂肪酸。
结果：关于NNR评分各组分的膳食摄入量，病例组多不饱和脂肪摄入量较低(15.41±4.44vs16.54±4.20g/天,p=0.01),维生素E（10.15±4.16vs13.1±5.33；p=0.001），维生素B1（2±0.86vs2.19±0.84毫克/天，p=0.03）和叶酸（516.45±96.59vs571.05±80.31；p=0.001）和更高的油酸摄入量（8.21±5.46vs5.59±3.17g/天，p=0.01）与对照组相比。调整混杂因素后，结直肠癌风险与NNR评分呈负相关(OR0.92;95%CI0.88至0.97;p=0.03)。
结论：低NNR评分可能与CRC相关。如果被未来的纵向研究证实，这一结果可能有助于通过推荐营养丰富的饮食来预防CRC.
方法：这项病例对照研究纳入了德黑兰地区160名35-70岁的结直肠癌患者和320名对照，伊朗。使用168项食物频率问卷评估饮食摄入量。通过计算包括蛋白质在内的14种营养素的平均每日值，获得NNR评分。维生素A,C,D,E,B1，B2，B12，钙，锌，铁,叶酸,钾和不饱和脂肪酸。
结果：关于NNR评分各组分的膳食摄入量，病例组多不饱和脂肪摄入量较低(15.41±4.44vs16.54±4.20g/天,p=0.01),维生素E（10.15±4.16vs13.1±5.33；p=0.001），维生素B1（2±0.86vs2.19±0.84毫克/天，p=0.03）和叶酸（516.45±96.59vs571.05±80.31；p=0.001）和更高的油酸摄入量（8.21±5.46vs5.59±3.17g/天，p=0.01）与对照组相比。调整混杂因素后，结直肠癌风险与NNR评分呈负相关(OR0.92;95%CI0.88至0.97;p=0.03)。
结论：低NNR评分可能与CRC相关。如果被未来的纵向研究证实，这一结果可能有助于通过推荐营养丰富的饮食来预防CRC.
