背景:采用Meta分析探讨信使核糖核酸(mRNA)表达与乳腺癌临床病理特征的相关性。
方法:英文数据库,PubMed,WebofScience,Embase,和Cochrane图书馆,等。,是用电脑搜索的.检索的时间范围设置为从数据库建立到2023年12月。搜索词设置为“mRNA”,“乳腺癌”,“病理学”,“临床病理特征”,等。筛选符合纳入和排除标准的文献,并提取数据供Revman5.3分析。
结果:最后,选择5篇合适的纳入文献,包括969名患者。分析结果发现mRNA表达与BC分级之间存在显着关联(OR=0.11,95%CI=0.04-0.30,Z=4.26,P<0.0001);mRNA表达与BC分期之间存在显着相关性(OR=0.19,95%CI=0.05-0.65,Z=2.65,P=0.008<0.05);在BC患者中,mRNA表达与月经状态之间没有相关性(OR=0.48%CI=0.88,在讨论部分,这项研究,包括10项研究,目的探讨信使核糖核酸与BC临床病理特征的相关性。BC的分期和分级,与肿瘤大小有一定的相关性,与BC患者的月经状况无相关性。
BACKGROUND: Meta analysis was adopted to investigate the correlation between messenger ribonucleic acid (mRNA) expression and clinicopathological features of breast cancer (BC).
METHODS: English databases, PubMed, Web of Science, Embase, and The Cochrane Library, etc., were searched using a computer. The time range of retrieval was set to be from the establishment of the database to December 2023. The search terms were set as \"mRNA\", \"Breast cancer\", \"Pathology\", \"Clinicopathological characteristics\", etc. The literatures were screened in line with the inclusion and exclusion criteria, and the data was extracted for analysis by Revman5.3.
RESULTS: Finally, 5 suitable included literatures were selected, including 969 patients. The analysis results were found to reveal a significant association between mRNA expression and BC grading (OR = 0.11, 95% CI = 0.04-0.30, Z = 4.26, P<0.0001); a significant correlation was observed between mRNA expression and BC staging (OR = 0.19, 95% CI = 0.05-0.65, Z = 2.65, P = 0.008<0.05); no correlation was found between mRNA expression and menstrual status of BC patients (OR = 0.63, 95% CI = 0.22-1.78, Z = 0.88, P = 0.38>0.05); a correlation was identified between mRNA expression and tumor size in BC (OR = 0.48, 95% CI = 0.24-0.99, Z = 2.00, P = 0.05). In the Discussion section, this study, comprising 10 research studies, aimed to explore the correlation between messenger ribonucleic acid and the clinical pathological features of BC. staging and grading of BC, a certain correlation with tumor size, and no correlation with the menstrual status of BC patients.