{Reference Type}: Journal Article
{Title}: Clinical and pathological spectrum of aortitis in a Chinese cohort.
{Author}: Qu W;Chen Y;Zhang Z;
{Journal}: Cardiovasc Pathol
{Volume}: 71
{Issue}: 0
{Year}: 2024 Jul-Aug 27
{Factor}: 3.975
{DOI}: 10.1016/j.carpath.2024.107651
{Abstract}: <B>BACKGROUND: </B>This study aimed to explore the clinical and pathological features of aortitis in China, which is a rare disease that is often overlooked preoperatively.<BR><B>METHODS: </B>We reviewed the records of 2950 patients who underwent aortic surgery at Wuhan Asia General Hospital from 2016 to 2023. Clinical and pathological data were collected and compared across different groups.<BR><B>RESULTS: </B>Out of 2950 patients, 15 had healed aortitis, 2 were healed Takayasu aortitis (TAK), and 13 were not further classified. Forty-two had active aortitis, including clinically isolated aortitis ([CIA], 42.9%), infectious aortitis ([IA], 26.2%), TAK (16.7%), and Behçet's syndrome ([BS], 14.3%), half of these cases were not recognized preoperatively. All patients who developed perivalvular leakage during follow-up had concurrent non-infectious valvulitis with mixed inflammatory pattern at the time of initial surgery. Seventeen out of 18 patients with CIA survived without complications, as did 8 out of 11 patients with IA, 6 out of 7 patients with TAK, and 2 out of 6 patients with BS.<BR><B>CONCLUSIONS: </B>Half of the aortitis cases were initially diagnosed by pathologists. Noninfectious valvulitis with mixed inflammatory pattern is a risk factor for perivalvular leakage. BS is associated with a higher rate of complications. Patients with CIA have a good prognosis in China, which is different from the West.