Abstract：
BACKGROUND: This study aimed to explore the clinical and pathological features of aortitis in China, which is a rare disease that is often overlooked preoperatively.
METHODS: We reviewed the records of 2950 patients who underwent aortic surgery at Wuhan Asia General Hospital from 2016 to 2023. Clinical and pathological data were collected and compared across different groups.
RESULTS: Out of 2950 patients, 15 had healed aortitis, 2 were healed Takayasu aortitis (TAK), and 13 were not further classified. Forty-two had active aortitis, including clinically isolated aortitis ([CIA], 42.9%), infectious aortitis ([IA], 26.2%), TAK (16.7%), and Behçet\'s syndrome ([BS], 14.3%), half of these cases were not recognized preoperatively. All patients who developed perivalvular leakage during follow-up had concurrent non-infectious valvulitis with mixed inflammatory pattern at the time of initial surgery. Seventeen out of 18 patients with CIA survived without complications, as did 8 out of 11 patients with IA, 6 out of 7 patients with TAK, and 2 out of 6 patients with BS.
CONCLUSIONS: Half of the aortitis cases were initially diagnosed by pathologists. Noninfectious valvulitis with mixed inflammatory pattern is a risk factor for perivalvular leakage. BS is associated with a higher rate of complications. Patients with CIA have a good prognosis in China, which is different from the West.
METHODS: We reviewed the records of 2950 patients who underwent aortic surgery at Wuhan Asia General Hospital from 2016 to 2023. Clinical and pathological data were collected and compared across different groups.
RESULTS: Out of 2950 patients, 15 had healed aortitis, 2 were healed Takayasu aortitis (TAK), and 13 were not further classified. Forty-two had active aortitis, including clinically isolated aortitis ([CIA], 42.9%), infectious aortitis ([IA], 26.2%), TAK (16.7%), and Behçet\'s syndrome ([BS], 14.3%), half of these cases were not recognized preoperatively. All patients who developed perivalvular leakage during follow-up had concurrent non-infectious valvulitis with mixed inflammatory pattern at the time of initial surgery. Seventeen out of 18 patients with CIA survived without complications, as did 8 out of 11 patients with IA, 6 out of 7 patients with TAK, and 2 out of 6 patients with BS.
CONCLUSIONS: Half of the aortitis cases were initially diagnosed by pathologists. Noninfectious valvulitis with mixed inflammatory pattern is a risk factor for perivalvular leakage. BS is associated with a higher rate of complications. Patients with CIA have a good prognosis in China, which is different from the West.
摘要：
背景：本研究旨在探讨中国主动脉炎的临床和病理特征，这是一种罕见的疾病，术前经常被忽视。
方法：回顾性分析2016-2023年武汉亚洲总医院2950例主动脉手术患者的临床资料。收集并比较不同组的临床和病理数据。
结果：在2950名患者中，15例主动脉炎治愈,2例已治愈的Takayasu主动脉炎（TAK）和13例未进一步分类。42患有活动性主动脉炎，包括临床孤立性主动脉炎(CIA，42.9%），感染性主动脉炎（IA，26.2%)，大动脉炎（TAK，16.7%），和Behçet综合征(BS，14.3%），这些病例中有一半在术前未被确认.所有在随访期间出现瓣膜周围渗漏的患者在初次手术时并发非感染性瓣膜炎并伴有混合炎症模式。18例CIA患者中有17例存活，没有并发症，11例IA患者中有8例，7名TAK患者中有6名，6例BS患者中有2例。
结论：一半的主动脉炎病例最初是由病理学家诊断的。混合炎症模式的非感染性瓣膜炎是瓣周漏的危险因素。BS与较高的并发症发生率相关。在中国，CIA患者预后良好，这与西方不同。
方法：回顾性分析2016-2023年武汉亚洲总医院2950例主动脉手术患者的临床资料。收集并比较不同组的临床和病理数据。
结果：在2950名患者中，15例主动脉炎治愈,2例已治愈的Takayasu主动脉炎（TAK）和13例未进一步分类。42患有活动性主动脉炎，包括临床孤立性主动脉炎(CIA，42.9%），感染性主动脉炎（IA，26.2%)，大动脉炎（TAK，16.7%），和Behçet综合征(BS，14.3%），这些病例中有一半在术前未被确认.所有在随访期间出现瓣膜周围渗漏的患者在初次手术时并发非感染性瓣膜炎并伴有混合炎症模式。18例CIA患者中有17例存活，没有并发症，11例IA患者中有8例，7名TAK患者中有6名，6例BS患者中有2例。
结论：一半的主动脉炎病例最初是由病理学家诊断的。混合炎症模式的非感染性瓣膜炎是瓣周漏的危险因素。BS与较高的并发症发生率相关。在中国，CIA患者预后良好，这与西方不同。
