背景:母亲在怀孕期间接触香烟烟雾可能在后代睾丸癌的发展中起作用。需要对现有证据进行更新和全面的系统审查。
目的:确定和评估孕妇在怀孕期间接触香烟烟雾和后代睾丸癌的现有证据。
方法:通过块搜索方法对PubMed中的英文同行评审原始文献进行系统搜索。如果评估母体暴露于香烟烟雾和后代患睾丸癌的风险,则考虑了出版物。
结果:在636条确定的记录中,14篇出版物有资格进行审查,10篇有资格进行荟萃分析。对出版物进行了质量评估。大多数纳入的出版物是病例对照研究(n=11,79%),其余为生态学研究(n=3,21%)。报告的完整性很高,但超过一半被认为存在潜在偏见.趋势综合显示,一半(n=7)的出版物表明,在怀孕期间暴露于香烟烟雾的母亲的儿子中,患睾丸癌的风险更高。荟萃分析得出的总体汇总风险估计值为1.00(95%CI:0.88;1.15)(n=10篇出版物),精原细胞瘤(0.79,95%CI:0.59;1.04)和非精原细胞瘤(0.96,95%CI:0.74;1.26)的风险较低(n=4篇文献).
结论:本系统评价未提供母亲暴露于香烟烟雾与后代患睾丸癌风险之间关联的证据。提出了总体积极趋势,但是它的统计精度很低。出版物的方法局限性鼓励基于有效的暴露数据进行进一步的研究。
BACKGROUND: Maternal exposure to cigarette smoke in pregnancy may play a role in the development of testicular cancer in offspring. An updated and comprehensive systematic
review of the available evidence is needed.
OBJECTIVE: To identify and evaluate current evidence on maternal exposure to cigarette smoke during pregnancy and testicular cancer in offspring.
METHODS: A systematic search of English peer-reviewed original literature in PubMed through a block search approach. Publications were considered if assessing maternal exposure to cigarette smoke and the risk of testicular cancer in offspring.
RESULTS: Among the 636 identified records, 14 publications were eligible for
review and 10 for meta-analysis. Quality assessment of the publications was conducted. Most included publications were case-control studies (n = 11, 79%), while the remaining were ecological studies (n = 3, 21%). Completeness of reporting was high, but more than half were considered subject to potential bias. The trend synthesis showed that half (n = 7) of the included publications demonstrated a higher risk of testicular cancer in the sons of mothers exposed to cigarette smoke during pregnancy. The meta-analysis generated an overall summary risk estimate of 1.00 (95% CI: 0.88; 1.15) (n = 10 publications), with a lower risk for seminoma (0.79, 95% CI: 0.59; 1.04) and nonseminoma (0.96, 95% CI: 0.74; 1.26) (n = 4 publications).
CONCLUSIONS: This systematic
review did not provide evidence of an association between maternal exposure to cigarette smoke and risk of testicular cancer in offspring. An overall positive trend was suggested, but it had low statistical precision. The methodological limitations across publications encourage further research based on valid exposure data.