背景：香烟烟雾和石棉是肺癌的公认原因，并共同促进癌变。目前，腺癌是美国肺癌的最常见原因，它与吸烟和石棉接触有关。表皮生长因子基因受体（EGFR）的突变主要发生在非吸烟者的腺癌中。方法采用新一代测序法检测EGFR基因突变。
结果：我们报告了三个职业暴露于石棉的从不吸烟者的肺腺癌中存在EGFR外显子点突变。
结论：石棉作为EGFR诱变的可能原因的作用需要进一步研究。Am.J、工业。Med.60:306-309,2017.©2017Wiley期刊，Inc.
BACKGROUND: Cigarette smoke and asbestos are recognized causes of lung carcinoma and together promote carcinogenesis. Adenocarcinoma is currently the most common cause of lung cancer in the USA and it has been linked to both smoking and asbestos exposure. Mutations in the epidermal growth factor gene receptor (EGFR) occur predominantly in non-smokers with adenocarcinoma. Methods Mutations in the EGFR gene were investigated using next-generation sequencing.
RESULTS: We report the presence of EGFR exon point mutations in the pulmonary adenocarcinomas of three never-smokers occupationally exposed to asbestos.
CONCLUSIONS: The role of asbestos as a possible cause of EGFR mutagenesis requires further investigation. Am. J. Ind. Med. 60:306-309, 2017. © 2017 Wiley Periodicals, Inc.
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