■尽管大多数患有酒精相关性肝病(ALD)的患者都有长期大量饮酒的病史,没有明确的阈值定义导致ALD的酒精消耗水平。我们旨在评估平均饮酒量与肝病风险之间的相关性,并确定临床上有意义的饮酒量的阈值。
■使用韩国国民健康保险数据库,我们确定了在2010年和2011年接受健康筛查的参与者,并对他们的数据进行了回顾性分析,直至2019年.要对提取的参与者进行诊断和分类,我们使用了国际疾病分类第10版和脂肪肝指数.主要结果是确定观察期间新诊断的肝脏相关疾病的发生率,并根据饮酒量比较非饮酒者和饮酒者之间肝脏相关疾病的发生率。
■共有53,006名患者入组并进行了中位8.4年的随访,在此期间发生了1,509例肝脏相关疾病。参与者分为五组:不饮酒(n=31,359),第一四分位数(n=5,242),第二四分位数(n=5,704),第三四分位数(n=5,337),和第四四分位数(n=5,364)。每个分位数(Q1,Q2,Q3和Q4)每周消耗的相应酒杯数标记为2.5±1.1标准单位(1个标准单位=8g酒精),5.4±1.9标准单位,11.5±3.3标准单位,和27.9±18.2标准单位,分别。与不饮酒者相比,发现Q1饮酒者患肝脏相关疾病的风险更高(调整后的风险比[AHR],1.09;95%CI,0.90-1.33),第二季度饮酒者(AHR,1.10;95%CI,0.91-1.32),Q3饮酒者(AHR,1.33;95%CI,1.11-1.59),和Q4饮酒者(AHR,1.47;95%CI,1.24-1.75)。
■我们报告说,我们的研究表明,饮酒超过11.5±3.3标准单位/周(92±26.4克/周)显着增加患肝脏相关疾病的风险。因此,作为降低患肝病风险的预防措施,酒精消费应限制在传统推荐水平之外。
UNASSIGNED: Although most patients with alcohol-related liver disease (ALD) have a history of prolonged and heavy drinking, there is no clear threshold defining the level of alcohol consumption that leads to ALD. We aimed to evaluate the correlation between average alcohol consumption and the risk of liver disease and to determine the threshold for clinically significant alcohol consumption.
UNASSIGNED: Using the Korean National Health Insurance database, we identified participants who underwent a health-screening program in 2010 and 2011 and retrospectively analyzed their data until 2019. To diagnose and categorize the extracted participants, we used the International Classification of Diseases version 10 and Fatty Liver Index. The primary outcome was to determine the incidence of newly diagnosed liver-related diseases during the observation period and compare the incidence of liver-related diseases among non-drinkers and drinkers based on the amount of alcohol consumption.
UNASSIGNED: A total of 53,006 patients were enrolled and followed-up for a median of 8.4 years, during which 1,509 cases of liver-related diseases occurred. The participants were divided into five groups: no alcohol consumption (n = 31,359), 1st quartile (n = 5,242), 2nd quartile (n = 5,704), 3rd quartile (n = 5,337), and 4th quartile (n = 5,364). The corresponding number of glasses of alcohol consumed per week for each quantile (Q1, Q2, Q3, and Q4) was labeled 2.5 ± 1.1 standard units (1 standard unit = 8 g alcohol), 5.4 ± 1.9 standard units, 11.5 ± 3.3 standard units, and 27.9 ± 18.2 standard units, respectively. Compared with non-drinkers, the risk of liver-related disease was found to be higher in Q1 drinkers (adjusted hazard ratio [aHR], 1.09; 95% CI, 0.90-1.33), Q2 drinkers (aHR, 1. 10; 95% CI, 0.91-1.32), Q3 drinkers (aHR, 1.33; 95% CI, 1.11-1.59), and Q4 drinkers (aHR, 1.47; 95% CI, 1.24-1.75).
UNASSIGNED: We report that our
study has shown that drinking more than 11.5 ± 3.3 standard units/week (92 ± 26.4 g/week) significantly increases the risk of developing liver-related diseases. Therefore, as a preventive measure to reduce the risk of developing liver disease, alcohol consumption should be limited beyond traditionally recommended levels.