PDF(Pubmed)
Abstract：
Background: The detection of fibrosis remains a necessity for the evaluation of hepatitis B virus (HBV)-infected patients, but the most accurate technique is invasive. Current studies aim to develop a novel noninvasive biomarker for fibrosis assessment, but no-one has found the ideal candidate. This study is a meta-analysis combined with a pilot study to investigate the connection between two transferase compounds and the levels of fibrosis. Methods: We studied data from PUBMED, Web of Science, and Scopus, retrieving 28,896 articles. Following PRISMA guidelines, we finally analyzed full-text articles written in English. The excluded items were duplicates, non-article entries, and irrelevant papers. We assessed the variations in alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) levels between patients with high and low levels of fibrosis. Joanna Briggs Institute tools were used to assess article quality. We used R 4.2.2 for statistics. The pilot study included 14 randomly chosen patients with different fibrosis levels. Results: We found significant differences in ALT and GGT levels between patients with high and low fibrosis. The GGT/ALT ratio correlated with the levels of fibrosis and the fibrosis-4 (FIB-4) score. Conclusions: This meta-analysis assessed ALT and GGT levels in chronic HBV patients with fibrosis. The pilot study identified the first association between fibrosis and the GGT/ALT ratio in a Romanian cohort of chronic patients. This brings new ideas for future research.
摘要：
背景：纤维化的检测仍然是一个必要的乙型肝炎病毒（HBV）感染的患者的评价，但最准确的技术是侵入性的.目前的研究旨在开发一种用于纤维化评估的新型非侵入性生物标志物，但是没有人找到理想的人选.这项研究是一项荟萃分析，并结合了一项初步研究，以研究两种转移酶化合物与纤维化水平之间的联系。方法：我们研究了来自PUBMED的数据，WebofScience,还有Scopus,检索28896篇文章。按照PRISMA准则,最后我们分析了全文用英语写的文章。排除的项目是重复的，非文章条目，和无关的文件。我们评估了高水平和低水平纤维化患者之间丙氨酸氨基转移酶（ALT）和γ-谷氨酰转移酶（GGT）水平的变化。JoannaBriggs研究所的工具用于评估文章质量。我们使用R4.2.2进行统计。初步研究包括14名随机选择的不同纤维化水平的患者。结果：我们发现高纤维化和低纤维化患者之间的ALT和GGT水平存在显着差异。GGT/ALT比值与纤维化水平和纤维化-4(FIB-4)评分相关。结论：这项荟萃分析评估了慢性HBV纤维化患者的ALT和GGT水平。初步研究确定了罗马尼亚慢性患者队列中纤维化与GGT/ALT比值之间的第一个关联。这为以后的研讨带来了新的思绪。
