背景:已发现重度抑郁症(MDD)在女性中的患病率几乎是男性的两倍。一个假设提出,受虐待的女性特别容易患MDD。我们旨在研究各种类型的儿童创伤与MDD之间的性别特异性关联。
方法:在本研究中,北京安定医院门诊诊断为MDD患者290人,从医院附近的社区招募了290名健康志愿者,关于性,年龄,和家族史相匹配。Bernstein等人开发的儿童创伤问卷简表(CTQ-SF)。用于评估五种不同类型的儿童虐待和忽视的严重程度。McNemar检验和具有潜在混杂因素的条件逻辑回归模型(即,婚姻状况,教育水平,和体重指数)控制用于探索不同类型的儿童虐待与MDD之间的性别相关性。
结果:在完整样本中,患有MDD的患者表现出明显更高的儿童虐待发生率(即,情感虐待,性虐待,身体虐待,情感上的忽视,和身体上的忽视)。在女性中,所有类型的儿童虐待均有统计学意义.对于男性来说,仅在情感虐待和情感忽视方面存在显着差异。
结论:门诊患者的MDD似乎与女性的任何类型的童年创伤和男性的情感虐待或忽视有关。
BACKGROUND: Major depressive disorder (MDD) has been found to be nearly twice as prevalent in females as in males. One hypothesis proposed that abused females were particularly prone to MDD. We aim to examine the sex-specific associations between various types of childhood trauma and MDD.
METHODS: In this study, 290 outpatients diagnosed with MDD were recruited from Beijing Anding Hospital, and 290 healthy volunteers were recruited from neighborhoods nearby the hospital, with sex, age, and family history matched. Childhood Trauma Questionnaire-Short Form (CTQ-SF) developed by Bernstein et al. was used to assess the severity of five different types of childhood abuse and neglect. McNemar\'s test and conditional logistic regression models with potential confounders (i.e., marital status, educational level, and body mass index) controlled were used to explore the sex-specific associations between different types of childhood maltreatment and MDD.
RESULTS: In the full sample, patients with MDD showed a significant higher rate of any childhood maltreatment (i.e., emotional abuse, sexual abuse, physical abuse, emotional neglect, and physical neglect). Among females, all types of childhood abuse were statistically significant. For males, significant differences were only found in emotional abuse and in emotional neglect.
CONCLUSIONS: It would appear that MDD in the outpatients is associated with any type of childhood trauma in women and emotional abuse or neglect in men.