■边缘性人格障碍(BPD)是一种复杂的心理健康状况,其特征是情绪不稳定,关系,自我形象,和行为。患有BPD的人经常在激烈的情绪中挣扎,冲动,保持稳定的关系。催产素,被称为“爱激素”或“结合激素”,“在社会纽带中起着至关重要的作用,信任,同理心,情绪调节及其失调可能导致BPD困难。本系统综述旨在分析现有文献,检查复杂的相互作用,并鼓励未来的研究和治疗策略。
■对PubMed文献的系统搜索,Embase和Psychinfo,没有任何语言或时间限制,直到2024年3月,将同义词库和与“边缘性人格障碍”和“催产素”相关的免费搜索索引术语组合在一起,产生310个结果(77个在PubMed,Embase中的166和Psychinfo中的67)。分析了94篇全文,共纳入70篇文献进行定性分析。
■催产素可能会影响依恋风格,父母的行为,和应激反应,特别是有童年创伤史的人。催产素之间的相互作用,遗传学,早期生活经历,和环境因素有助于BPD的复杂性。催产素受体基因的遗传变异可能会影响社交和情感能力,并有助于精神病理学的发展。此外,早期不良经历,比如童年的虐待,可以改变催产素的功能,影响社会认知和情绪调节。然而,催产素在BPD治疗中的作用仍不确定,一些研究表明,避免社会威胁等特定症状的潜在益处,而其他人则表明对非语言行为和心理化的不利影响。
■了解催产素在BPD中的作用可以为潜在的治疗干预措施提供见解。虽然基于催产素的治疗可能有望解决特定症状,需要进一步的研究。
UNASSIGNED: Borderline personality disorder (BPD) is a complex mental health condition marked by instability in mood, relationships, self-image, and behavior. Individuals with BPD often struggle with intense emotions, impulsivity, and maintaining stable relationships. Oxytocin, known as the \"love hormone\" or \"bonding hormone,\" plays a crucial role in social bonding, trust, empathy, and emotional regulation and its dysregulation may contribute to BPD difficulties. This systematic
review aims to analyze existing literature, examining the intricate interplay and encouraging future research and treatment strategies.
UNASSIGNED: A systematic search of Literature in PubMed, Embase and Psychinfo, without any language or time restriction, was performed until March 2024 combining thesaurus and free-search indexing terms related to \"borderline personality disorder\" and \"oxytocin\", producing 310 results (77 in PubMed, 166 in Embase and 67 in Psychinfo). Ninety-four full texts were analyzed, and 70 articles were included in qualitative analysis.
UNASSIGNED: Oxytocin may influence attachment styles, parental behaviors, and stress responses, particularly in individuals with a history of childhood trauma. The interaction between oxytocin, genetics, early life experiences, and environmental factors contributes to the complexity of BPD. Genetic variations in the oxytocin receptor gene may influence social and emotional abilities and contribute to the development of psychopathology. Additionally, early adverse experiences, such as childhood maltreatment, can alter oxytocin functioning, impacting social cognition and emotional regulation.However, oxytocin\'s role in BPD treatment remains uncertain, with some studies suggesting potential benefits for specific symptoms like social threat avoidance, while others indicate adverse effects on nonverbal behavior and mentalizing.
UNASSIGNED: Understanding oxytocin\'s role in BPD offers insights into potential therapeutic interventions. While oxytocin-based treatments may hold promise for addressing specific symptoms, further research is needed.