背景:大多数食物依赖性运动引起的过敏反应(FDEIA)是由食用小麦或甲壳类动物引起的。然而,水果或蔬菜可能很少充当FDEIA的过敏原。我们报告了一种罕见的因食用胡萝卜引起的FDEIA病例。案例介绍:一个8岁的男孩在玩耍时出现了过敏反应,吃完午餐后,包括煮熟的胡萝卜。血清胡萝卜特异性免疫球蛋白E水平为0.19UA/mL。生胡萝卜的逐刺试验为阳性(风团直径:4mm)。患者在摄入生胡萝卜后进行运动激发试验后出现荨麻疹。通过2维Western印迹分析胡萝卜蛋白以鉴定致病过敏原。9种蛋白质被鉴定为21-66kDa的候选抗原。结论:我们的患者在摄入生胡萝卜和煮熟的胡萝卜后都出现了FDEIA症状。生胡萝卜和煮熟的胡萝卜都含有9种可能诱导FDEIA的蛋白质。
Background: Most cases of food-dependent exercise-induced anaphylaxis (FDEIA) are caused by eating wheat or crustaceans. However, fruits or vegetables may rarely act as allergens for FDEIA. We report a rare
case of FDEIA caused by eating carrots.
Case Presentation: An 8-year-old boy developed an anaphylactic reaction while playing, after eating lunch that included cooked carrots. Serum
carrot-specific immunoglobulin E level was 0.19 UA/mL. The prick-by-prick test for raw carrots was positive (wheal diameter: 4 mm). The patient developed urticaria after exercise provocation tests following ingestion of raw carrots.
Carrot proteins were analyzed by 2-dimensional Western blotting to identify the causative allergens. Nine proteins were identified as candidate antigens at 21-66 kDa. Conclusions: Our patient presented with FDEIA symptoms after ingesting both raw and cooked carrots. Both raw and cooked carrots contain 9 proteins that may induce FDEIA.