■恶性高血压是最严重的高血压形式,可能导致危及生命的表现。卡马西平是一种主要用于癫痫发作和三叉神经痛的抗癫痫药物。卡马西平很少触发的不良副作用之一是药物引起的恶性高血压。这里,我们准备介绍首例来自尼泊尔的卡马西平诱发恶性高血压病例报告.
■这里,我们的目的是提供1例病例报告,1例26岁女性有全身性强直-阵挛性癫痫发作史,该患者在开始服用卡马西平后出现了新发高血压,尽管有几次降压治疗,但最终在停药卡马西平后缓解.病人随后在我们的机构接受了治疗,其中左乙拉西坦用作替代品。患者正在密切随访监测血压图。
■虽然罕见,各种心血管副作用,包括卡马西平导致的高血压,已被报道。卡马西平通过诱导细胞色素P450起作用,促进几种抗高血压药物的早期代谢和清除,导致它们在高血压中的作用降低。确切的病因仍有争议。然而,药物卡马西平的去除可能导致高血压的缓解,如几篇文献所示。
■恶性高血压在极少数情况下是由于使用药物卡马西平引起的。随后停止卡马西平治疗可以缓解高血压。在这种情况下,定期进行血压监测和制图至关重要。
UNASSIGNED: Malignant hypertension is the most severe form of hypertension that may cause life-threatening manifestations.
Carbamazepine is an antiepileptic drug primarily used for seizure disorders and trigeminal neuralgia. One of the rarely triggered adverse side effects of
carbamazepine is drug-induced malignant hypertension. Here, we intend to present the first case report of
carbamazepine-induced malignant hypertension from Nepal.
UNASSIGNED: Here, we aim to present a case report of a 26-year-old female with a history of generalized tonic-clonic seizure who had developed de-novo hypertension after initiation of carbamazepine with no decrease in blood pressure to normal levels despite several antihypertensive administrations which eventually resolved on the discontinuation of drug carbamazepine. The patient was subsequently managed at our institution, where levetiracetam was used as an alternative. The patient was in close follow-up monitoring blood pressure charting.
UNASSIGNED: Although rare, a variety of cardiovascular side effects, including hypertension led by the drug carbamazepine, have been reported.
Carbamazepine acts by inducing cytochrome P450, which facilitates an early metabolism and clearance of several antihypertensive medications, causing a decrease in their role in hypertension. The exact etiology is still debatable. However, the removal of the drug carbamazepine may result in a remission of hypertension, as illustrated in several literatures.
UNASSIGNED: Malignant hypertension is caused in rare cases to the use of the drug carbamazepine. The hypertension can undergo remission by subsequent discontinuation of the
carbamazepine therapy. Regular blood pressure monitoring and charting are crucial in such cases.