■COX-2相对于健康的结肠粘膜在结直肠肿瘤组织中过表达,因此,我们研究了COX-2在确定结直肠癌患者转移中的预后意义。
■PubMed,EMBASE,使用以下术语搜索Cochrane图书馆,结肠癌,直肠癌,大肠癌,环氧合酶-2和预后,以确定提供COX-2在成人转移性结直肠癌患者中预后重要性信息的文章。审查文件,非研究信件,注释,病例报告,动物研究,样本量小于20的原始研究,病例报告和系列,非英语语言文章,儿科研究(17岁以下)被排除.使用纽卡斯尔渥太华量表(NOS)评估纳入研究的可信度。对全文进行了评估,本研究符合当地协议和《赫尔辛基宣言》的规定。
■本综述纳入了8项相关研究,涉及937例患者。荟萃分析显示COX-2表达与淋巴结浸润有关(RR1.85[1.21,2.83],P=0.005,I2=88%)和肝转移(RR4.90[1.12,21.57],P=0.04,I2=42%),但没有静脉播散(RR1.48[0.72,3.03],P=0.28,I2=87%)。
■COX-2的表达与结直肠癌淋巴结浸润有关,但需要进一步的研究来确定COX-2的表达在确定结直肠癌患者转移状态中的预后意义。
UNASSIGNED: COX-2 is overexpressed in colorectal tumour tissue relative to the healthy colonic mucosa, thus we investigated the prognostic significance of COX-2 in determining the metastasis of patients with colorectal cancer.
UNASSIGNED: PubMed, EMBASE, and Cochrane Library were searched using the following terms colorectal cancer, colon cancer, rectal cancer, colorectal carcinoma, Cyclooxygenase-2, and prognosis to identify articles providing information on the prognostic importance of COX-2 in adult patients with metastatic colorectal cancer.
Review papers, non-research letters, comments, case reports, animal studies, original research with sample sizes of fewer than 20, case reports and series, non-English language articles, and pediatric studies (those under the age of 17) were excluded. The Newcastle Ottawa Scale (NOS) was used to assess the credibility of the included studies. The full texts were evaluated and this study complied with the terms of the local protocol and the Helsinki Declaration.
UNASSIGNED: Eight relevant studies were included in this
review involving 937 patients. The meta-analysis revealed that COX-2 expression is associated with lymph node invasion (RR 1.85 [1.21, 2.83], P = 0.005, I2 = 88 %) and liver metastasis (RR 4.90 [1.12, 21.57], P = 0.04, I2 = 42 %), but not with venous dissemination (RR 1.48 [0.72, 3.03], P = 0.28, I2 = 87 %).
UNASSIGNED: COX-2 expression is associated with lymph node invasion in colorectal cancer but further studies are required to determine the prognostic significance of COX-2 expression in determining metastasis status for colorectal cancer patients.