Abstract：
Inhibitors of COX-2 constitute a class of anti-inflammatory analgesics, showing potential against certain types of cancer. However, such inhibitors are associated with cardiovascular toxicity. Moreover, although single-target molecules possess specificity for particular targets, they often lead to poor safety, low efficacy and drug resistance due to compensatory mechanisms. A new generation of dual-target drugs that simultaneously inhibit COX-2 and another target is showing strong potential to treat cancer or reduce adverse cardiac effects. The present perspective focuses on the structure and functions of COX-2, and its role as a therapeutic target. It also explores the current state and future possibilities for dual-target strategies from a medicinal chemistry perspective.
摘要：
COX-2抑制剂构成了一类抗炎镇痛药,显示出对抗某些类型癌症的潜力。然而,这些抑制剂与心血管毒性有关。此外，尽管单靶标分子对特定靶标具有特异性，它们经常导致安全性差，由于代偿机制的低疗效和耐药性。同时抑制COX-2和另一个靶标的新一代双靶标药物显示出治疗癌症或减少不良心脏作用的强大潜力。本观点关注COX-2的结构和功能及其作为治疗靶标的作用。它还从药物化学的角度探讨了双目标策略的当前状态和未来可能性。
