未经证实:免疫系统受损的人类免疫缺陷病毒(HIV)感染者的2019年冠状病毒病(COVID-19)可能与严重并发症的更大风险有关。迄今为止,尚未进行全面的研究来评估COVID-19患者中的HIV。在本研究中,我们对合并感染严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)和HIV的患者的状态进行了系统评价和荟萃分析.
UNASSIGNED:通过回顾Medline上发表的原始研究文章,进行了系统的文献检索策略,WebofScience,2019年和2020年的Embase数据库。采用STATA软件进行统计分析,版本14.0(Stata公司,学院站,德州,美国),报告COVID-19患者中HIV的患病率。病例报告/病例系列也作为系统评价进行了评估。
UNASSIGNED:本研究纳入了63项研究(53例病例报告/病例系列和10项患病率研究)。对患病率研究的荟萃分析显示,在6个国家/地区报告了COVID-19患者中的HIV感染(乌干达,中国,伊朗,美国,意大利,和西班牙),在14424例COVID-19患者中,总频率为1.2%[(95%CI)0.8-1.7]。根据病例报告和病例系列,据报道,来自19个国家的113名COVID-19患者中有111名HIV患者。大多数病例发生在美国,中国,意大利,和西班牙。
UNASSIGNED:文献中报道的SARS-CoV-2-HIV共感染患者数量很少,因此很难得出确切的结论。然而,由于HIV感染者更有可能发生更严重的COVID-19并发症,因此应考虑采取有针对性的政策来应对当前大流行中这种增加的风险.我们的发现强调了识别潜在疾病的重要性,共同感染,合并症,实验室发现,以及在COVID-19大流行期间对HIV患者的有益治疗策略。
UNASSIGNED: Coronavirus disease 2019 (COVID-19) in people living with human immunodeficiency virus (HIV) who has a compromised immune system can be associated with more significant risks for severe complications. To date, no comprehensive study has been performed to evaluate HIV in patients with COVID-19. In the present study, we assessed the status of patients co-infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and HIV as a systematic
review and meta-analysis.
UNASSIGNED: A systematic literature search strategy was conducted via reviewing original research articles published in Medline, Web of Science, and Embase databases in 2019 and 2020. Statistical analysis was performed using STATA software, version 14.0 (Stata Corporation, College Station, Texas, USA), to report the prevalence of HIV among patients with COVID-19. Case reports/case series were also evaluated as a systematic
review.
UNASSIGNED: Sixty-three studies (53 case reports/case series and ten prevalence studies) were included in our study. A meta-analysis of prevalence studies showed that HIV infection among patients with COVID-19 was reported in 6 countries (Uganda, China, Iran, USA, Italy, and Spain) with an overall frequency of 1.2% [(95% CI) 0.8-1.7] among 14,424 COVID-19 patients. According to the case reports and case series, 111 patients with HIV have been reported among 113 patients with COVID-19 from 19 countries. Most of the cases were in the USA, China, Italy, and Spain.
UNASSIGNED: The small number of SARS-CoV-2-HIV co-infected patients reported in the literature makes it difficult to draw precise conclusions. However, since people with HIV are more likely to develop more severe complications of COVID-19, targeted policies to address this raised risk in the current pandemic should be considered. Our findings highlight the importance of identifying underlying diseases, co-infections, co-morbidities, laboratory findings, and beneficial treatment strategies for HIV patients during the COVID-19 pandemic.