PDF(Pubmed)
Abstract：
One of the biggest threats to human well-being and public health is antibiotic resistance. If allowed to spread unchecked, it might become a major health risk and trigger another pandemic. This proves the need to develop antibiotic resistance-related global health solutions that take into consideration microdata from various global locations. Establishing positive social norms, guiding individual and group behavioral habits that support global human health, and ultimately raising public awareness of the need for such action could all have a positive impact. Antibiotic resistance is not just a growing clinical concern but also complicates therapy, making adherence to current guidelines for managing antibiotic resistance extremely difficult. Numerous genetic components have been connected to the development of resistance; some of these components have intricate paths of transfer between microorganisms. Beyond this, the subject of antibiotic resistance is becoming increasingly significant in medical microbiology as new mechanisms underpinning its development are identified. In addition to genetic factors, behaviors such as misdiagnosis, exposure to broad-spectrum antibiotics, and delayed diagnosis contribute to the development of resistance. However, advancements in bioinformatics and DNA sequencing technology have completely transformed the diagnostic sector, enabling real-time identification of the components and causes of antibiotic resistance. This information is crucial for developing effective control and prevention strategies to counter the threat.
摘要：
对人类福祉和公共卫生的最大威胁之一是抗生素耐药性。如果允许不受控制地传播，它可能成为主要的健康风险，并引发另一场大流行。这证明有必要开发与抗生素耐药性相关的全球健康解决方案，并考虑到来自全球各地的微观数据。建立积极的社会规范，指导支持全球人类健康的个人和群体行为习惯，最终提高公众对采取此类行动的必要性的认识都可能产生积极影响。抗生素耐药性不仅是一个日益增长的临床问题，而且使治疗复杂化。使遵守当前指南管理抗生素耐药性极其困难。许多遗传成分与抗性的发展有关；其中一些成分在微生物之间具有复杂的转移路径。除此之外,随着支持抗生素耐药性发展的新机制被发现，抗生素耐药性在医学微生物学中变得越来越重要。除了遗传因素,误诊等行为，接触广谱抗生素，和延迟诊断有助于耐药性的发展。然而,生物信息学和DNA测序技术的进步彻底改变了诊断领域，能够实时识别抗生素耐药性的成分和原因。这些信息对于制定有效的控制和预防战略以应对威胁至关重要。
