背景:以前的自然流产与先兆子痫之间的关系尚未完全了解。本研究旨在评估苏丹孕妇先前的自然流产与先兆子痫之间的关系。
方法:在SaadAbuelela医院进行了一项病例对照研究(每个研究组包括180名妇女),喀土穆,苏丹。病例均为子痫前期孕妇,对照组包括健康孕妇。参与者的社会人口统计,产科,和临床特征通过问卷进行评估。
结果:年龄无显著差异,奇偶校验,教育水平,就业状况,血型,身体质量指数,患者和对照组之间的血红蛋白水平。对照组40例(22.2%)先兆子痫妇女和68例(37.8%)妇女有自然流产史(p=0.001)。多因素logistic回归分析(调整)显示,有自然流产史的妇女比没有自然流产史的妇女发生先兆子痫的风险更低[调整比值比(AOR)=0.44,95%置信区间(CI)=0.26-0.73]。然而,有先兆子痫病史的女性先兆子痫复发的风险较高(AOR=1.92,95%CI=1.11~3.32).
结论:本研究显示,先前的自然流产将先兆子痫的风险降低了59.0%。
BACKGROUND: The association between previous spontaneous abortion and preeclampsia is not yet fully understood. The current study was conducted to assess the association between previous spontaneous abortion and preeclampsia among pregnant women in Sudan.
METHODS: A
case-control study (involving 180 women in each study group) was conducted at Saad Abuelela Hospital, Khartoum, Sudan. The cases were pregnant women with preeclampsia, while the control group included healthy pregnant women. The participants\' sociodemographic, obstetric, and clinical characteristics were assessed via a questionnaire.
RESULTS: There was no significant difference in the age, parity, education level, employment status, blood group, body mass index, and hemoglobin level between the patient and control groups. Forty (22.2%) women with preeclampsia and 68 (37.8%) women in the control group had a history of spontaneous abortion (p = 0.001). Multivariate logistic regression analysis (adjusted) revealed that women with a history of spontaneous abortion had a lower risk of preeclampsia than those without a history of spontaneous abortion [adjusted odds ratio (AOR) = 0.44, 95% confidence interval (CI) = 0.26‒0.73]. However, women with a history of preeclampsia had a higher risk of recurrence of preeclampsia (AOR = 1.92, 95% CI = 1.11‒3.32).
CONCLUSIONS: The present study revealed that previous spontaneous abortion reduced the risk of preeclampsia by 59.0%.