METHODS: A woman with gestational age 28 weeks and 5 days, received emergent Cesarean section because of fetal distress. The baby was expired at the next day after delivery and the comprehensive study showed severe anemia and alloimmunization related hemolysis caused by anti-E due to high antibody titer (1: 4096).
CONCLUSIONS: Anti-E antibody is one of the most common non-Rhesus D antibodies in the pathogenesis of HDFN, but rarely leads to severe hemolysis. However, our case has the highest reported anti-E titer in HDFN and is the first case of mortality during the past 15 years in NCKUH.
方法:一名胎龄28周零5天的妇女,因胎儿宫内窘迫接受了紧急剖腹产手术.婴儿在分娩后第二天过期,综合研究显示,由于高抗体滴度(1:4096),由抗E引起的严重贫血和同种免疫相关溶血。
结论:抗E抗体是HDFN发病机制中最常见的非恒河猴D抗体之一,但很少导致严重溶血。然而,我们的病例在HDFN中报告的抗E滴度最高,是过去15年来CKUH首例死亡病例.