背景:头皮银屑病是全科医生最常见和最具挑战性的斑块状银屑病表现之一,皮肤科医生,和病人,因为成功的局部管理需要选择有效成分,适当的配方,并向患者提供明确的应用说明。迄今为止,卡泊三醇(50μg/g)/二丙酸倍他米松(0.5mg/g)气雾剂泡沫制剂(Cal/BD泡沫)治疗头皮银屑病的经验有限.
方法:在这个瑞士真实病例系列中,我们要求10名连续的活动性头皮银屑病患者在睡前每天一次使用Cal/BD泡沫,为期4周.提供了清除应用和冲洗说明书。
结果:在2019年4月至5月期间,共有10名连续的成年患者接受了治疗。两名患者患有轻度,五个来自中度,和三个来自严重的头皮牛皮癣。10个病人中有8个,头皮牛皮癣是疾病的唯一表现。所有患者以前都接受过局部治疗,主要是外用皮质类固醇(TCS),焦油洗发水,和水杨酸。用Cal/BD泡沫治疗4周后,在5分严重程度评估量表上,所有10例患者的头皮银屑病改善≥2分.治疗4周后,10名患者中有8名获得了清晰/几乎清晰的皮肤,不需要进一步的角质层剥离治疗。在任何患者中均未观察到不良事件。总的来说,患者对易用性非常满意,功效,和Cal/BD泡沫的安全性。
结论:我们的病例系列证实Cal/BD泡沫是一种快速,有效,在未选择的现实世界患者队列中,对TCS或其他局部治疗无效的局部头皮银屑病进行便捷治疗。明确的应用说明对于治疗成功和接受化妆品至关重要,however.
BACKGROUND: Scalp psoriasis is one of the most common and challenging manifestations of plaque psoriasis for general practitioners, dermatologists, and patients, as successful topical management requires the choice of effective ingredients, an appropriate formulation, and clear application instructions to patients. To date, only limited experience is available for the calcipotriol (50 μg/g)/
betamethasone dipropionate (0.5 mg/g) aerosol foam formulation (Cal/BD foam) in the treatment of scalp psoriasis.
METHODS: In this Swiss real-world patient
case series, we asked 10 consecutive patients with active scalp psoriasis to apply the Cal/BD foam once daily before bedtime for a period of 4 weeks. Clear application and rinse-off instructions were provided.
RESULTS: A total of 10 consecutive adult patients were treated between April and May 2019. Two patients suffered from mild, five from moderate, and three from severe scalp psoriasis. In eight out of the 10 patients, scalp psoriasis was the only manifestation of disease. All patients had received previous topical treatments, mainly topical corticosteroids (TCS), tar shampoo, and salicylic acid. After 4 weeks of treatment with Cal/BD foam, the scalp psoriasis improved in all 10 patients by ≥ 2 points on a 5-point severity assessment scale. Eight out of 10 patients achieved clear/almost clear skin after 4 weeks of treatment, with no further keratolytic treatments needed. Adverse events were not observed in any of the patients. Overall, patients were very satisfied with the ease of use, the efficacy, and the safety of the Cal/BD foam.
CONCLUSIONS: Our
case series confirms that Cal/BD foam is a rapid, effective, and convenient treatment for localized scalp psoriasis in a nonselected real-world patient cohort refractory to TCS or other local treatments. Clear application instructions are crucial for treatment success and cosmetic acceptance, however.