着床是与不孕症相关的病理过程中的关键点,尤其是子宫内膜异位症。在这个复杂的过程中,只有有限的证据证明了接受性和自噬的作用.本研究旨在评估LC3A/B,P62/SQSTM1,Beclin1和整合素在子宫内膜异位症妊娠大鼠子宫内膜异位症第6天的表达和接受性和自噬过程。对照组大鼠均妊娠(8/8),子宫内膜异位症组的妊娠率为4/8,6/8子宫内膜异位症+ALA组。子宫内膜异位症+ALA组LC3A/B和P62/SQSTM1表达显著增高,与子宫内膜异位症组相比(p<0.05)。ALA对子宫内膜异位症细胞自噬和容受性的影响首次被证实。应研究子宫内膜异位症的抗氧化和抗炎治疗作为植入问题的新治疗方式。实际应用:子宫内膜异位症,其病因仍然未知,是不孕不育的重要原因。着床是与不孕症相关的病理过程中的关键点。在这个复杂的过程中,只有有限的证据证明了接受性和自噬的作用.本研究旨在评估LC3A/B,P62/SQSTM1,Beclin1和整合素在子宫内膜异位症妊娠大鼠子宫内膜异位症第6天的表达和接受性和自噬过程。将口服α-硫辛酸给予一组,并评估这种强抗氧化剂对该过程的影响。
Implantation is a key point in pathological processes associated with infertility, especially in endometriosis. In this complex process, there is limited evidence to demonstrate the role of receptivity and autophagy. The present
study aimed to evaluate LC3A/B, P62/SQSTM1, Beclin 1, and integrin expressions and receptivity and autophagy processes in endometriosis in pregnant rats with healthy endometriosis on day 6 of the process. Pregnancy was observed in all rats in the control group (8/8), while the pregnancy was 4/8 in the endometriosis group, and 6/8 in the endometriosis + ALA group. LC3A/B and P62/SQSTM1 expression increased significantly in the endometriosis + ALA group, compared with endometriosis groups (p < .05). The effect of ALA on autophagy and receptivity in endometriosis was shown for the first time. Antioxidant and anti-inflammatory treatments in endometriosis should be investigated as new treatment modalities for implantation problems. PRACTICAL APPLICATIONS: Endometriosis, the etiology of which remains unknown, is an important cause of infertility. Implantation is the key point in pathological processes associated with infertility. In this complex process, there is limited evidence to demonstrate the role of receptivity and autophagy. The present
study aimed to evaluate LC3A/B, P62/SQSTM1, Beclin 1, and integrin expressions and receptivity and autophagy processes in endometriosis in pregnant rats with healthy endometriosis on day 6 of the process. Oral alpha-lipoic acid was administered to one group and the effect of this powerful antioxidant on the process was evaluated.