目标:虽然平价,不孕症,初生的年龄对心血管疾病的后期发展很重要,关于它们与心房颤动(AF)关联的研究有限.
方法:我们将基于人群的HUNT研究的数据联系起来,挪威医学出生登记处(MBRN)和当地医院验证的医疗记录。共有24,015名年龄在45岁或以上的妇女被追踪,以核实事件AF。从MBRN或HUNT的自我报告问卷中检索了初生时的均等和年龄。不孕症病史在HUNT问卷上自我报告。Cox比例风险模型用于计算奇偶校验的多变量调整关联的风险比(HR),不孕症,和有房颤风险的第一胎年龄。
结果:在12.8年的中位随访期间,1,448名(6.0%)参与者发生房颤。性别较高的妇女(四个或更多的分娩与两胎)房颤风险高21%(HR1.21,95%置信区间(CI),1.05-1.39)。不孕史也与房颤风险相关(HR1.20,95%CI,1.02-1.42)。在妇女中,第一次出生时年龄较小(<20岁vs.20-29年)与房颤风险增加20%(HR1.20,95%CI,1.03-1.40)相关。
结论:四胎或四胎以上的妇女,或者有不孕症史,在45岁以上的女性中,第一次分娩时或更小的年龄发生房颤的风险高出约20%.
出生次数越多,初生时年龄越小,患心血管疾病(CVD)的风险越高。然而,关于平等之间关联的证据有限,初产年龄和心房颤动(AF)。此外,不孕症和房颤之间的关联在很大程度上仍未被研究.我们已经调查了奇偶校验之间的关联,不孕症,在45岁以上女性中,来自挪威的基于人群的队列(HUNT研究)中的第一胎年龄和AF。我们的研究结果表明,生育四个或四个以上的妇女,或者有不孕症史,第一次分娩时年龄或年龄较小的人患房颤的风险增加约20%.
OBJECTIVE: Although parity, infertility, and age at first birth are important for later development of cardiovascular disease, research on their association with atrial fibrillation (AF) is limited.
METHODS: We linked data from the population-based HUNT
study, the Medical Birth Registry of Norway (MBRN) and validated medical records from local hospitals. A total of 24,015 women aged 45 years or older were followed for verified incident AF. Parity and age at first birth were retrieved from the MBRN or from self-reported questionnaires in the HUNT. History of infertility was self-reported on the HUNT questionnaire. Cox-proportional hazard models were used to calculate hazard ratios (HR) for the multivariable-adjusted associations of parity, infertility, and age at first birth with risk of AF.
RESULTS: During a median follow-up of 12.8 years, 1,448 (6.0%) participants developed AF. Women with higher parity (four or more births vs. two births) were at 21% higher risk of AF (HR 1.21, 95% confidence interval (CI), 1.05-1.39). History of infertility was also associated with risk of AF (HR 1.20, 95% CI, 1.02-1.42). Among parous women, younger age at first birth (<20 years vs. 20-29 years) was associated with a 20% higher risk of AF (HR 1.20, 95% CI, 1.03-1.40).
CONCLUSIONS: Women with four or more births, or a history of infertility, or younger age at first birth have approximately a 20% higher risk of AF among women over 45 years old.
A higher number of births and younger age at first birth are associated with a higher risk of cardiovascular disease (CVD). However, there is limited evidence on the associations between parity, age at first birth and atrial fibrillation (AF). Moreover, the association between infertility and AF remains largely unexplored. We have investigated the association between parity, infertility, age at first birth and AF in the population-based cohort from Norway (the HUNT
study) among women over 45 years old. Our findings reveal that women with four or more births, or a history of infertility, or younger age at first birth have approximately a 20% higher risk of AF.