目的:本研究旨在探讨哮喘、相关的过敏和药物使用,以及密歇根大学牙科学院个体牙周炎的存在和严重程度。
方法:采用案例控制设计,这项研究分析了892名患者的数据,一半患有哮喘,一半没有哮喘。数据收集包括人口统计,哮喘病史,药物使用,过敏,和牙周检查结果,包括探测袋深度(PPD),移动性,分叉参与,和影像学骨丢失(RBL)。Logistic回归模型评估哮喘和牙周炎之间的关系,适应混杂因素。
结果:与非哮喘患者相比,哮喘患者患牙周炎的几率明显降低(OR=0.10,p<.001),并且不太可能出现晚期(OR=0.23,p<.001)和疾病等级(OR=0.31,p<.001)。研究还发现,哮喘组中女性比例较高(67%vs.51.8%,p<.001)。吸烟被认为是与哮喘患者牙周炎相关的重要因素,前吸烟者的赔率超过两倍(OR=2.28,p=0.035),而当前吸烟者的赔率略低但显着(OR=1.87,p=0.050)。此外,使用肾上腺素能吸入器的哮喘患者发生牙周炎的可能性增加(OR=1.76,p=.045).对可待因和乳胶过敏与较高的牙周炎几率相关,ORs分别为3.41和6.09。
结论:发现哮喘与牙周炎的几率较低有关。然而,这种联系似乎被吸烟习惯和某些哮喘药物的使用所改变,这与哮喘患者患牙周炎的可能性增加有关。
OBJECTIVE: This study aimed to investigate the
association between asthma, related allergies and medication use, and the presence and severity of periodontitis among individuals at the University of Michigan School of Dentistry.
METHODS: Employing a
case-control design, the study analyzed data from 892 patients, half with asthma and half without asthma. Data collection included demographics, asthma history, medication use, allergies, and periodontal examination outcomes, including probing pocket depth (PPD), mobility, furcation involvement, and radiographic bone loss (RBL). Logistic regression models assessed the relationship between asthma and periodontitis, adjusting for confounders.
RESULTS: Asthmatic patients exhibited significantly lower odds of periodontitis (OR = 0.10, p < .001) and were less likely to present with advanced stages (OR = 0.23, p < .001) and grades of the disease (OR = 0.31, p < .001) compared to non-asthmatic patients. The study also found a higher proportion of females in the asthmatic group (67% vs. 51.8%, p < .001). Smoking was identified as a significant factor associated with periodontitis in patients with asthma, with former smokers at more than double the odds (OR = 2.28, p = .035) and current smokers at a slightly lower yet significant odds (OR = 1.87, p = .050). Additionally, asthmatic patients on adrenergic inhalers had an increased likelihood of developing periodontitis (OR = 1.76, p = .045). Allergies to codeine and latex were associated with higher odds of periodontitis, with ORs of 3.41 and 6.09, respectively.
CONCLUSIONS: Asthma was found to be associated with lower odds of periodontitis. However, this
association appears to be modified by smoking habits and the use of certain asthma medications, which are related to an increased likelihood of periodontitis among asthmatic patients.