PDF(Pubmed)
Abstract：
Adiponectin, a hormone secreted by adipose tissue, plays a complex role in regulating metabolic homeostasis and has also garnered attention for its potential involvement in the pathogenesis of late-onset Alzheimer\'s disease (LOAD). The objective of this study was to investigate the association of ADIPOQ variants with plasma adiponectin levels and LOAD risk in subjects from the Slovak Caucasian population. For this purpose, 385 LOAD patients and 533 controls without cognitive impairment were recruited and genotyped for a total of eighteen ADIPOQ single nucleotide polymorphisms (SNPs). Both single-locus and haplotype-based logistic regression analyses were employed to assess the association of SNPs with LOAD risk, while linear regression analysis was used to explore their influence on adiponectin levels in LOAD patients. ADIPOQ variants rs822395 and rs2036373 in intron 1 were found to significantly elevate total adiponectin levels after accounting for several potential confounders. Additional SNPs in the 5\' region and intron 1 exhibited a non-significant trend of association with adiponectin. However, none of the ADIPOQ SNPs showed an association with LOAD risk, neither in the whole-group analysis nor in subgroup analyses after stratification for sex or the APOE ε4 allele, a well-established LOAD risk factor. In summary, while adiponectin has emerged as a potential contributor to the development of LOAD, this study did not unveil any significant involvement of its gene variants in susceptibility to the disease.
摘要：
脂联素,一种由脂肪组织分泌的激素,在调节代谢稳态方面发挥着复杂的作用，并且由于其可能参与迟发性阿尔茨海默病（LOAD）的发病机制而引起了人们的关注。这项研究的目的是调查斯洛伐克高加索人群中ADIPOQ变体与血浆脂联素水平和LOAD风险的关联。为此,招募了385名LOAD患者和533名没有认知障碍的对照，并对总共18个ADIPOQ单核苷酸多态性（SNP）进行了基因分型。采用基于单基因座和单倍型的逻辑回归分析来评估SNP与LOAD风险的关联。线性回归分析对LOAD患者脂联素水平的影响。发现内含子1中的ADIPOQ变体rs822395和rs2036373在考虑了几种潜在的混杂因素后显着提高了总脂联素水平。在5'区和内含子1中的其他SNP表现出与脂联素相关的非显著趋势。然而,ADIPOQSNP均未显示与LOAD风险相关，无论是在整组分析还是在性别或APOEε4等位基因分层后的亚组分析中，一个公认的负载风险因素。总之,虽然脂联素已成为LOAD发展的潜在贡献者，这项研究没有揭示其基因变异与该疾病的易感性有任何显著关系.
