背景:没有研究描述12周延长的维持间隔期免疫治疗在预防进口火蚁(IFA)叮咬过敏反应方面的功效。
目的:本研究的目的是确定IFA免疫治疗患者12周维持间隔的安全性和有效性。
方法:在至少3个月的常规维持间期免疫治疗和基线疗效验证后,IFA超敏反应的成年人被前瞻性地纳入研究,并将他们的维持剂量延长至6-,8-,和12周的间隔。通过每年的IFA刺激挑战确认了疗效。
结果:共有25名患者开始延长维持间期免疫治疗。8例患者的初始全身反应的严重程度为轻度(32%);10例患者为中度(40%),7例患者为重度(28%)。18例患者进入试验时的维持免疫治疗持续时间少于3年(平均11个月;范围3-28个月),4例患者3~5年(平均46个月,范围36~57个月),5例患者超过5年(平均111个月;范围67-197个月)。治疗队列没有经历延长间隔注射的全身反应,集群再填充注射,野外刺痛,或刺痛的挑战。
结论:这项前瞻性纵向队列研究表明,在已接受至少3个月维持剂量IFAWBE免疫治疗的18岁以上的成年人中,延长至12周的EMI是一种安全有效的治疗选择.延长维护间隔的好处包括减少注射次数,诊所就诊,以及维持免疫疗法的失误。
There are no studies describing 12-week extended maintenance interval (EMI) immunotherapy (IT) efficacy in preventing anaphylaxis to imported fire ant (IFA) stings.
The purpose of this
study was to determine the safety and efficacy of 12-week maintenance intervals in patients treated with IFA IT.
After a minimum of 3 months of conventional maintenance interval IT and verification of baseline efficacy, adults with IFA hypersensitivity were prospectively enrolled and extended their maintenance doses to 6-, 8-, and 12-week intervals. Efficacy was confirmed by means of an annual IFA sting challenge.
A total of 25 patients initiated EMI. The severity of their initial systemic reactions was mild in 8 patients (32%), moderate in 10 patients (40%), and severe in 7 patients (28%). Maintenance IT duration at
trial entry was less than 3 years in 18 patients (mean 11 months; range 3-28 months), 3 to 5 years in 4 patients (mean 46 months; range 36-57 months), and greater than 5 years in 5 patients (mean 111 months; range 67-197 months). The treatment cohort did not experience systemic reactions to extended interval injections, cluster refill injections, field stings, or sting challenges.
This prospective longitudinal cohort
study revealed that in adults 18 years old or older who have received at least 3 months of maintenance dose IFA-whole body extract IT with proven efficacy, extension to a 12-week EMI is a safe effective treatment option. The benefits of EMI include a reduced number of injections, clinic visits, and lapses in maintenance IT.