■报告临床表现,眼前节光学相干断层扫描特征,治疗,与翼状胬肉相关的眼表鳞状细胞瘤(OSSN)的结果。
■在28个月的研究期间,对14例病例进行回顾性介入治疗。
■OSSN与翼状胬肉(n=14)共存于<1%的翼状胬肉(n=7384)。OSSN伴翼状胬肉的平均年龄为49岁(中位数,49年;范围,36至71岁)。转诊诊断包括翼状胬肉无OSSN(n=7,50%),肉芽肿(n=1,7%),光化性角化病(n=1,7%),和结膜炎(n=1,7%)。所有OSSN都是单边的,6例患者(43%)有双侧翼状胬肉。肿瘤起源于鼻部(n=8,57%),或时间(n=6,43%)象限。平均肿瘤直径为4毫米(中位数,4mm;范围,2至6毫米),平均厚度为2mm(中位数,1mm;范围,1至3毫米)。在所有(100%)病例中,都可以在眼前段光学相干断层扫描(AS-OCT)上确定OSSN和翼状胬肉之间的轮廓。所有患者接受1%外用5-氟尿嘧啶(5-FU),13例(93%)患者的肿瘤完全消退,平均2个周期(中位数,两个循环;范围,1至4个周期)。无明显不良反应。在平均11个月的随访期内,没有发现肿瘤复发(中位数为12个月;范围,1至4个月)。
■AS-OCT可以准确检测和标测伴有翼状胬肉的OSSN中的肿瘤范围,和局部5-FU产生优异的肿瘤控制。
UNASSIGNED: To report the clinical presentation, anterior segment optical coherence tomography features, treatment, and outcomes of ocular surface squamous neoplasia (OSSN) associated with pterygium.
UNASSIGNED: Retrospective interventional series of 14 cases in a 28-month study period.
UNASSIGNED: OSSN was coexistent with pterygium (n = 14) in < 1% of all pterygia (n = 7384). The mean age at the presentation of OSSN with pterygium was 49 years (median, 49 years; range, 36 to 71 years). Referral diagnosis included pterygium sans OSSN (n = 7, 50%), granuloma (n = 1, 7%), actinic keratosis (n = 1, 7%), and conjunctivitis (n = 1, 7%). All OSSNs were unilateral, and six patients (43%) had bilateral pterygia. Tumors arose from the nasal (n = 8, 57%), or temporal (n = 6, 43%) quadrants. The mean tumor diameter was 4 mm (median, 4 mm; range, 2 to 6 mm), and the mean thickness was 2 mm (median, 1 mm; range, 1 to 3 mm). The delineation between OSSN and pterygium could be identified on anterior segment optical coherence tomography (AS-OCT) in all (100%) cases. All patients received 1% topical 5-fluorouracil (5-FU), and complete tumor regression was achieved in 13 (93%) cases with a mean number of 2 cycles (median, two cycles; range, 1 to 4 cycles). There were no significant adverse effects. No tumor recurrence was noted over a mean follow-up period of 11 months (median 12 months; range, 1 to 4 months).
UNASSIGNED: AS-OCT allows accurate detection and mapping of tumor extent in OSSN with coexistent pterygium, and topical 5-FU yields excellent tumor control.