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Abstract：
Glaucoma patients often suffer from ocular surface disease (OSD) caused by the chronic administration of topical anti-glaucoma medications, especially in cases of long-term therapy with preserved or multiple drugs. Additionally, glaucoma surgery may determine ocular surface changes related to the formation and location of the filtering bleb, the application of anti-mitotic agents, and the post-operative wound-healing processes within the conjunctiva. Recently, several studies have evaluated the role of advanced diagnostic imaging technologies such as in vivo confocal microscopy (IVCM) and anterior segment-optical coherence tomography (AS-OCT) in detecting microscopic and macroscopic features of glaucoma therapy-related OSD. Their clinical applications are still being explored, with recent particular attention paid to analyzing the effects of new drug formulations and of minimally invasive surgical procedures on the ocular surface status. In this review, we summarize the current knowledge about the main changes of the ocular surface identified at IVCM and AS-OCT in glaucoma patients under medical therapy, or after surgical treatment.
摘要：
青光眼患者通常患有由局部抗青光眼药物的长期服用引起的眼表疾病（OSD），特别是在长期使用保留或多种药物治疗的情况下。此外,青光眼手术可以确定与滤过泡的形成和位置相关的眼表变化，抗有丝分裂剂的应用，和结膜内的术后伤口愈合过程。最近,多项研究评估了先进的诊断成像技术,如体内共聚焦显微镜(IVCM)和眼前节光学相干断层扫描(AS-OCT)在检测青光眼治疗相关OSD的微观和宏观特征中的作用.其临床应用仍在探索中,最近特别注意分析新药物制剂和微创外科手术对眼表状态的影响。在这次审查中,我们总结了目前关于在药物治疗下的青光眼患者在IVCM和AS-OCT上确定的眼表主要变化的知识，或手术治疗后。
